Thomas A Owen
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Explore the profile of Thomas A Owen including associated specialties, affiliations and a list of published articles.
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20
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534
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Recent Articles
11.
Buckbinder L, Crawford D, Qi H, Ke H, Olson L, Long K, et al.
Proc Natl Acad Sci U S A
. 2007 Jun;
104(25):10619-24.
PMID: 17537919
Bone is accrued and maintained primarily through the coupled actions of bone-forming osteoblasts and bone-resorbing osteoclasts. Cumulative in vitro studies indicated that proline-rich tyrosine kinase 2 (PYK2) is a positive...
12.
Song J, Aswad R, Kanaan R, Rico M, Owen T, Barbe M, et al.
J Cell Physiol
. 2006 Nov;
210(2):398-410.
PMID: 17111364
Mesenchymal cell (MC) condensation or the aggregation of MCs precedes chondrocyte differentiation and is required for subsequent cartilage formation during endochondral ossification. In this study, we used micromass cultures of...
13.
Abdelmagid S, Barbe M, Arango-Hisijara I, Owen T, Popoff S, Safadi F
J Cell Physiol
. 2006 Oct;
210(1):26-37.
PMID: 17034042
Our laboratory previously showed that osteoactivin (OA) is a novel, osteoblast-related glycoprotein that plays a role in osteoblast differentiation and function. The purpose of this study was to examine the...
14.
Ke H, Crawford D, Qi H, Simmons H, Owen T, Paralkar V, et al.
J Bone Miner Res
. 2006 Apr;
21(4):565-75.
PMID: 16598377
Unlabelled: CP432 is a newly discovered, nonprostanoid EP4 receptor selective prostaglandin E2 agonist. CP432 stimulates trabecular and cortical bone formation and restores bone mass and bone strength in aged ovariectomized...
15.
Cameron K, Lefker B, Chu-Moyer M, Crawford D, Jardine P, DeNinno S, et al.
Bioorg Med Chem Lett
. 2006 Jan;
16(7):1799-802.
PMID: 16442794
Heptanoic acid lactams, exemplified by 2, were identified as highly selective EP4 agonists via high throughput screening. Lead optimization led to the identification of lactams with a 30-fold increase in...
16.
Chesworth R, Wessel M, Heyden L, Mangano F, Zawistoski M, Gegnas L, et al.
Bioorg Med Chem Lett
. 2005 Oct;
15(24):5562-6.
PMID: 16219463
A series of ligands with varying heterocyclic cores and substituents that display a range of selectivity's (up to >100x) for ER-beta over ER-alpha are reported.
17.
Chesworth R, Zawistoski M, Lefker B, Cameron K, Day R, Mangano F, et al.
Bioorg Med Chem Lett
. 2004 May;
14(11):2729-33.
PMID: 15125923
Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER alpha and ER beta selective analogs.
18.
Selim A, Abdelmagid S, Kanaan R, Smock S, Owen T, Popoff S, et al.
Crit Rev Eukaryot Gene Expr
. 2003 Dec;
13(2-4):265-75.
PMID: 14696973
Osteoactivin (OA) is a novel protein identified by mRNA differential display using bone from osteopetrotic versus normal rats. Bioinformatic analysis showed that OA cDNA has an open reading frame of...
19.
Li M, Ke H, Qi H, Healy D, Li Y, Crawford D, et al.
J Bone Miner Res
. 2003 Nov;
18(11):2033-42.
PMID: 14606517
Unlabelled: CP-533,536, a newly discovered, non-prostanoid EP2 receptor-selective PGE2 agonist, stimulates local bone formation and enhances fracture healing in rat models. Introduction: There is a significant medical need for agents...
20.
Safadi F, Xu J, Smock S, Kanaan R, Selim A, Odgren P, et al.
J Cell Physiol
. 2003 May;
196(1):51-62.
PMID: 12767040
Connective tissue growth factor (CTGF) is a secreted, extracellular matrix-associated signaling protein that regulates diverse cellular functions. In vivo, CTGF is expressed in many tissues with highest levels in the...