Thijn R Brummelkamp
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Explore the profile of Thijn R Brummelkamp including associated specialties, affiliations and a list of published articles.
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96
Citations
13099
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Recent Articles
1.
Manzo S, Mazouzi A, Leemans C, van Schaik T, Neyazi N, van Ruiten M, et al.
EMBO J
. 2024 Sep;
43(21):5260-5287.
PMID: 39322756
Lamina-associated domains (LADs) are large chromatin regions that are associated with the nuclear lamina (NL) and form a repressive environment for transcription. The molecular players that mediate gene repression in...
2.
Nyame K, Xiong J, Alsohybe H, de Jong A, Pena I, de Miguel R, et al.
bioRxiv
. 2024 Jun;
PMID: 38895439
Lysosomes catabolize lipids and other biological molecules, a function essential for cellular and organismal homeostasis. Key to lipid catabolism in the lysosome is bis(monoacylglycero)phosphate (BMP), a major lipid constituent of...
3.
Bak J, Brummelkamp T, Perrakis A
FEBS Lett
. 2024 May;
598(12):1453-1464.
PMID: 38811347
Microtubules are a major component of the cytoskeleton and can accumulate a plethora of modifications. The microtubule detyrosination cycle is one of these modifications; it involves the enzymatic removal of...
4.
Boon N, Oliveira R, Korner P, Kochavi A, Mertens S, Malka Y, et al.
Science
. 2024 May;
384(6697):785-792.
PMID: 38753784
In response to excessive DNA damage, human cells can activate p53 to induce apoptosis. Cells lacking p53 can still undergo apoptosis upon DNA damage, yet the responsible pathways are unknown....
5.
Miao B, Hu Z, Mezzadra R, Hoeijmakers L, Fauster A, Du S, et al.
Cancer Cell
. 2023 Sep;
41(10):1817-1828.e9.
PMID: 37683639
The dysregulated expression of immune checkpoint molecules enables cancer cells to evade immune destruction. While blockade of inhibitory immune checkpoints like PD-L1 forms the basis of current cancer immunotherapies, a...
6.
McLelland G, Lopez-Osias M, Verzijl C, Ellenbroek B, Oliveira R, Boon N, et al.
Nature
. 2023 Aug;
621(7977):171-178.
PMID: 37648867
Triacylglycerols (TAGs) are the main source of stored energy in the body, providing an important substrate pool for mitochondrial beta-oxidation. Imbalances in the amount of TAGs are associated with obesity,...
7.
Mazouzi A, Moser S, Abascal F, van den Broek B, Del Castillo Velasco-Herrera M, van der Heijden I, et al.
Sci Adv
. 2023 May;
9(22):eadf4409.
PMID: 37256941
DNA interstrand crosslinks (ICLs) pose a major obstacle for DNA replication and transcription if left unrepaired. The cellular response to ICLs requires the coordination of various DNA repair mechanisms. Homologous...
8.
Koob L, Friskes A, van Bergen L, Feringa F, van den Broek B, Koeleman E, et al.
Mol Oncol
. 2023 May;
17(7):1192-1211.
PMID: 37195379
Faithful and timely repair of DNA double-strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co-factor MND1 facilitates the repair of...
9.
Bak J, Landskron L, Brummelkamp T, Perrakis A
J Vis Exp
. 2023 Mar;
(193).
PMID: 36939268
Microtubules are an important part of the cytoskeleton and are involved in intracellular organization, cell division, and migration. Depending on the posttranslational modifications, microtubules can form complexes with various interacting...
10.
Haahr P, Galli R, van den Hengel L, Bleijerveld O, Kazokaite-Adomaitiene J, Song J, et al.
Science
. 2022 Sep;
377(6614):1533-1537.
PMID: 36173861
Protein synthesis generally starts with a methionine that is removed during translation. However, cytoplasmic actin defies this rule because its synthesis involves noncanonical excision of the acetylated methionine by an...