Theresa C Swayne
Overview
Explore the profile of Theresa C Swayne including associated specialties, affiliations and a list of published articles.
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24
Citations
466
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Recent Articles
1.
Yang E, Boldogh I, Ji H, Pon L, Swayne T
J Vis Exp
. 2023 Jun;
(196).
PMID: 37335116
Mitochondrial dysfunction, or functional alteration, is found in many diseases and conditions, including neurodegenerative and musculoskeletal disorders, cancer, and normal aging. Here, an approach is described to assess mitochondrial function...
2.
Asgarkhani L, Khandakar I, Pakan R, Swayne T, Emtage L
bioRxiv
. 2023 Feb;
PMID: 36824970
Aggregation of mutant Huntingtin protein (mHtt) leads to neuronal cell death and human disease. We investigated the effect of inclusion formation on yeast cells. Previous work indicates that mHtt protein...
3.
Liao P, Yang E, Borgman T, Boldogh I, Sing C, Swayne T, et al.
Front Cell Dev Biol
. 2022 Mar;
10:852021.
PMID: 35281095
Lipid droplets (LDs) have emerged not just as storage sites for lipids but as central regulators of metabolism and organelle quality control. These critical functions are achieved, in part, at...
4.
Sing C, Yang E, Higuchi-Sanabria R, Pon L, Boldogh I, Swayne T
Methods Mol Biol
. 2021 Sep;
2364:81-100.
PMID: 34542849
Budding yeast, Saccharomyces cerevisiae, is an appealing model organism to study the organization and function of the actin cytoskeleton. With the advent of techniques to perform high-resolution, multidimensional analysis of...
5.
Sing C, Yang E, Swayne T, Higuchi-Sanabria R, Tsang C, Boldogh I, et al.
Methods Mol Biol
. 2021 Sep;
2364:53-80.
PMID: 34542848
Although budding yeast, Saccharomyces cerevisiae, is widely used as a model organism in biological research, studying cell biology in yeast was hindered due to its small size, rounded morphology, and...
6.
Pei S, Swayne T, Morris J, Emtage L
Commun Biol
. 2021 Aug;
4(1):971.
PMID: 34400761
The processes underlying formation and growth of unfolded protein inclusions are relevant to neurodegenerative diseases but poorly characterized in living cells. In S. cerevisiae, inclusions formed by mutant huntingtin (mHtt)...
7.
Liao P, Higuchi-Sanabria R, Swayne T, Sing C, Pon L
Methods Cell Biol
. 2020 Mar;
155:519-544.
PMID: 32183975
Mitochondria are highly dynamic organelles that undergo directed movement and anchorage, which in turn are critical for calcium buffering and energy mobilization at specific regions within cells or at sites...
8.
Aktar F, Burudpakdee C, Polanco M, Pei S, Swayne T, Lipke P, et al.
Life Sci Alliance
. 2019 Sep;
2(5).
PMID: 31527136
Inclusions of disordered protein are a characteristic feature of most neurodegenerative diseases, including Huntington's disease. Huntington's disease is caused by expansion of a polyglutamine tract in the huntingtin protein; mutant...
9.
Guardia-Laguarta C, Liu Y, Lauritzen K, Erdjument-Bromage H, Martin B, Swayne T, et al.
J Neurosci
. 2019 Jul;
39(36):7074-7085.
PMID: 31300519
Maintaining a pool of functional mitochondria requires degradation of damaged ones within the cell. PINK1 is critical in this quality-control process: loss of mitochondrial membrane potential causes PINK1 to accumulate...
10.
Pernice W, Swayne T, Boldogh I, Pon L
Front Cell Dev Biol
. 2018 Jan;
5:120.
PMID: 29359129
Tethers that link mitochondria to other organelles are critical for lipid and calcium transport as well as mitochondrial genome replication and fission of the organelle. Here, we review recent advances...