Theresa Alenghat
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Explore the profile of Theresa Alenghat including associated specialties, affiliations and a list of published articles.
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48
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4392
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Recent Articles
1.
Hari Gopal S, Alenghat T, Pammi M
Pediatr Res
. 2024 Sep;
PMID: 39289593
Epigenetics is the study of changes in gene expression, without a change in the DNA sequence that are potentially heritable. Epigenetic mechanisms such as DNA methylation, histone modifications, and small...
2.
Stevens J, Culberson E, Kinder J, Ramiriqui A, Gray J, Bonfield M, et al.
bioRxiv
. 2024 Apr;
PMID: 38645130
The immunological defects causing susceptibility to severe viral respiratory infections due to early-life dysbiosis remain ill-defined. Here, we show that influenza virus susceptibility in dysbiotic infant mice is caused by...
3.
Didriksen B, Eshleman E, Alenghat T
Mucosal Immunol
. 2024 Mar;
17(2):303-313.
PMID: 38428738
The mammalian gastrointestinal tract hosts a diverse community of trillions of microorganisms, collectively termed the microbiota, which play a fundamental role in regulating tissue physiology and immunity. Recent studies have...
4.
Eshleman E, Rice T, Potter C, Waddell A, Hashimoto-Hill S, Woo V, et al.
Immunity
. 2024 Jan;
57(2):319-332.e6.
PMID: 38295798
Tuft cells in mucosal tissues are key regulators of type 2 immunity. Here, we examined the impact of the microbiota on tuft cell biology in the intestine. Succinate induction of...
5.
Shao T, Jiang T, Stevens J, Russi A, Troutman T, Bernieh A, et al.
Cell Rep
. 2023 Oct;
42(11):113323.
PMID: 37889750
Intestinal colonization by antigenically foreign microbes necessitates expanded peripheral immune tolerance. Here we show commensal microbiota prime expansion of CD4 T cells unified by the Kruppel-like factor 2 (KLF2) transcriptional...
6.
Velez Lopez A, Waddell A, Antonacci S, Castillo D, Santucci N, Ollberding N, et al.
Neurogastroenterol Motil
. 2023 Sep;
35(12):e14681.
PMID: 37736865
Background & Aims: Disorders of gut-brain interaction (DGBI) are complex conditions that result in decreased quality of life and a significant cost burden. Linaclotide, a guanylin cyclase C (GCC) receptor...
7.
8.
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation
Overcast G, Meibers H, Eshleman E, Saha I, Waggoner L, Patel K, et al.
J Exp Med
. 2023 Mar;
220(6).
PMID: 36976181
Intestinal epithelial cells (IECs) constitute a critical first line of defense against microbes. While IECs are known to respond to various microbial signals, the precise upstream cues regulating diverse IEC...
9.
Eshleman E, Shao T, Woo V, Rice T, Engleman L, Didriksen B, et al.
J Clin Invest
. 2023 Jan;
133(4).
PMID: 36602872
Aberrant immune responses to resident microbes promote inflammatory bowel disease and other chronic inflammatory conditions. However, how microbiota-specific immunity is controlled in mucosal tissues remains poorly understood. Here, we found...
10.
Grasset E, Alenghat T
Immunity
. 2022 Dec;
55(12):2222-2224.
PMID: 36516815
Cellular dynamics that influence mucosal healing are not well understood. In this issue of Immunity, Frede, Czarnewski, Monasterio et al. find that B cells accumulate in the colon following intestinal...