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Tetsuya Terasaki

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Articles 245
Citations 5919
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Recent Articles
1.
Mallick R, Montaser A, Komi H, Juusola G, Tirronen A, Gurzeler E, et al.
Mol Ther . 2025 Mar; PMID: 40083161
Vascular endothelial growth factor B186 (VEGF-B186), a ligand for VEGF receptor 1 (VEGFR1) and neuropilin (NRP), promotes vascular growth in healthy and ischemic myocardium. However, the mechanisms and signaling of...
2.
Tampio J, Montaser A, Jarvinen J, Lehtonen M, Jalkanen A, Reinisalo M, et al.
Eur J Pharm Sci . 2024 Oct; 203:106937. PMID: 39419128
l-type amino acid transporter 1 (LAT1) is a membrane transporter responsible for carrying large, neutral l-configured amino acids as well as appropriate (pro)drugs into a cell. It has shown a...
3.
Ramsay E, Montaser A, Niitsu K, Urtti A, Auriola S, Huttunen K, et al.
Mol Pharm . 2024 May; 21(7):3204-3217. PMID: 38809137
The transcorneal route is the main entry route for drugs to the intraocular parts, after topical administration. The outer surface, the corneal epithelium (CE), forms the rate-limiting barrier for drug...
4.
Merivaara A, Puranen J, Sadeghi A, Zashikhina N, Pirskanen L, Lajunen T, et al.
J Control Release . 2024 Apr; 370:1-13. PMID: 38615893
Lipid-based drug formulations are promising systems for improving delivery of drugs to ocular tissues, such as retina. To develop lipid-based systems further, an improved understanding of their pharmacokinetics is required,...
5.
Prieto Garcia L, Vildhede A, Nordell P, Ahlstrom C, Montaser A, Terasaki T, et al.
CPT Pharmacometrics Syst Pharmacol . 2024 Apr; 13(6):1029-1043. PMID: 38576225
Statins are used to reduce liver cholesterol levels but also carry a dose-related risk of skeletal muscle toxicity. Concentrations of statins in plasma are often used to assess efficacy and...
6.
Kataoka H, Akiyoshi T, Uchida Y, Imaoka A, Terasaki T, Ohtani H
J Pharm Sci . 2024 Mar; 113(5):1376-1384. PMID: 38432624
Organic anion transporting polypeptide (OATP)1A2 and OATP2B1 have potential N-glycosylation sites, but their influence remains unclear. This study aimed to identify the N-glycosylation sites of OATP1A2/2B1 and investigate their impact...
7.
Del Amo E, Vellonen K, Urtti A, Terasaki T, Hammid A, Honkakoski P, et al.
Mass Spectrom Rev . 2023 Aug; PMID: 37530668
Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to...
8.
Ramsay E, Lajunen T, Bhattacharya M, Reinisalo M, Rilla K, Kidron H, et al.
J Control Release . 2023 Jul; 361:1-19. PMID: 37481214
Retinal drug delivery is a challenging, but important task, because most retinal diseases are still without any proper therapy. Drug delivery to the retina is hampered by the anatomical and...
9.
Ishiguro H, Mizuno T, Uchida Y, Sato R, Sasaki H, Nemoto S, et al.
NAR Genom Bioinform . 2023 Mar; 5(1):lqad022. PMID: 36915410
Transcriptomic data of cultured cells treated with a chemical are widely recognized as useful numeric information that describes the effects of the chemical. This property is due to the high...
10.
Huttunen J, Kronenberger T, Montaser A, Kralova A, Terasaki T, Poso A, et al.
Mol Pharm . 2023 Jan; 20(2):1331-1346. PMID: 36688491
Membrane transporters are the key determinants of the homeostasis of endogenous compounds in the cells and their exposure to drugs. However, the substrate specificities of distinct transporters can overlap. In...