Tess R Malcolm
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Explore the profile of Tess R Malcolm including associated specialties, affiliations and a list of published articles.
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14
Citations
102
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Recent Articles
1.
Malcolm T, Klein M, Petkovic K, Smith I, Blasdell K
Pathogens
. 2025 Jan;
14(1).
PMID: 39861003
Current arbovirus surveillance strategies in Australia involve mosquito collection, species identification, and virus detection. These processes are labour-intensive, expensive, and time-consuming and can lead to delays in reporting. Mosquito excreta...
2.
Blasdell K, Ploeg R, Hobbs E, Muhi S, Riddell S, Cunneen A, et al.
Sci Rep
. 2024 Oct;
14(1):25352.
PMID: 39455716
Buruli ulcer (BU) is a necrotizing disease of skin and soft tissue caused by the bacterium Mycobacterium ulcerans (MU). In Australia, where the disease is emerging in new geographic areas...
3.
Giannangelo C, Challis M, Siddiqui G, Edgar R, Malcolm T, Webb C, et al.
Elife
. 2024 Jul;
13.
PMID: 38976500
New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of M1 alanyl metalloaminopeptidase as an...
4.
Edgar R, Malcolm T, Siddiqui G, Giannangelo C, Counihan N, Challis M, et al.
mBio
. 2024 May;
15(6):e0096624.
PMID: 38717141
To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound is a selective, nanomolar...
5.
Anderson A, Crameri J, Ang C, Malcolm T, Kang Y, Baker M, et al.
EMBO Rep
. 2023 Jun;
24(8):e56430.
PMID: 37272231
Human Tim8a and Tim8b are paralogous intermembrane space proteins of the small TIM chaperone family. Yeast small TIMs function in the trafficking of proteins to the outer and inner mitochondrial...
6.
Mubarak S, Malcolm T, Brown H, Hanssen E, Maher M, McColl G, et al.
Biochemistry
. 2023 Apr;
62(9):1484-1496.
PMID: 37014173
The nematode contains genes for two types of ferritin ( and ) that express FTN-1 and FTN-2. We have expressed and purified both proteins and characterized them by X-ray crystallography,...
7.
Calic P, Vinh N, Webb C, Malcolm T, Ngo A, Lowes K, et al.
Eur J Med Chem
. 2023 Jan;
248:115051.
PMID: 36634455
Malaria remains a global health threat and growing resistance to artemisinin-based therapies calls for therapeutic agents with novel mechanisms of action. The Plasmodium spp M1 and M17 metalloaminopeptidases have been...
8.
Edgar R, Siddiqui G, Hjerrild K, Malcolm T, Vinh N, Webb C, et al.
Elife
. 2022 Sep;
11.
PMID: 36097817
the causative agent of malaria, remains a global health threat as parasites continue to develop resistance to antimalarial drugs used throughout the world. Accordingly, drugs with novel modes of action...
9.
Webb C, Yang W, Riley B, Hayes B, Sivaraman K, Malcolm T, et al.
J Biol Chem
. 2022 Jun;
298(7):102119.
PMID: 35691342
The metal-dependent M17 aminopeptidases are conserved throughout all kingdoms of life. This large enzyme family is characterized by a conserved binuclear metal center and a distinctive homohexameric arrangement. Recently, we...
10.
Neville S, Sjohamn J, Watts J, MacDermott-Opeskin H, Fairweather S, Ganio K, et al.
Sci Adv
. 2021 Aug;
7(32).
PMID: 34362732
Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC) permeases serve as the primary import pathway for many micronutrients including the first-row transition metal manganese....