Chaille T Webb
Overview
Explore the profile of Chaille T Webb including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
31
Citations
697
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Giannangelo C, Challis M, Siddiqui G, Edgar R, Malcolm T, Webb C, et al.
Elife
. 2024 Jul;
13.
PMID: 38976500
New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of M1 alanyl metalloaminopeptidase as an...
2.
Pitman E, Counihan N, Modak J, Chowdury M, Gilson P, Webb C, et al.
Front Cell Infect Microbiol
. 2024 Jan;
13:1332146.
PMID: 38282616
Apicomplexan parasites that reside within a parasitophorous vacuole harbor a conserved pore-forming protein that enables small-molecule transfer across the parasitophorous vacuole membrane (PVM). In parasites that cause malaria, this nutrient...
3.
Germany E, Thewasano N, Imai K, Maruno Y, Bamert R, Stubenrauch C, et al.
Elife
. 2024 Jan;
12.
PMID: 38226797
Outer membrane proteins (OMPs) are essential components of the outer membrane of Gram-negative bacteria. In terms of protein targeting and assembly, the current dogma holds that a 'β-signal' imprinted in...
4.
Cun W, Bate C, Srikhanta Y, Hutton M, Webb C, Revitt-Mills S, et al.
J Med Chem
. 2023 Dec;
67(1):450-466.
PMID: 38112278
With the aim of discovering small molecule inhibitors of the sporulation process in , we prepared a series of C-7 α-(4-substituted-1-1,2,3-triazol-1-yl)acetamide analogues of cefotetan, a known inhibitor of the sporulation-specific...
5.
Mansouri M, Daware K, Webb C, McGowan S
Curr Opin Struct Biol
. 2023 Sep;
82:102693.
PMID: 37657352
Malaria continues to be the most widespread parasitic disease affecting humans globally. As parasites develop drug resistance at an alarming pace, it has become crucial to identify novel drug targets....
6.
Rosas N, Wilksch J, Barber J, Li J, Wang Y, Sun Z, et al.
Elife
. 2023 Jul;
12.
PMID: 37410078
Antibiotic resistance is driven by selection, but the degree to which a bacterial strain's evolutionary history shapes the mechanism and strength of resistance remains an open question. Here, we reconstruct...
7.
Calic P, Vinh N, Webb C, Malcolm T, Ngo A, Lowes K, et al.
Eur J Med Chem
. 2023 Jan;
248:115051.
PMID: 36634455
Malaria remains a global health threat and growing resistance to artemisinin-based therapies calls for therapeutic agents with novel mechanisms of action. The Plasmodium spp M1 and M17 metalloaminopeptidases have been...
8.
Edgar R, Siddiqui G, Hjerrild K, Malcolm T, Vinh N, Webb C, et al.
Elife
. 2022 Sep;
11.
PMID: 36097817
the causative agent of malaria, remains a global health threat as parasites continue to develop resistance to antimalarial drugs used throughout the world. Accordingly, drugs with novel modes of action...
9.
Webb C, Yang W, Riley B, Hayes B, Sivaraman K, Malcolm T, et al.
J Biol Chem
. 2022 Jun;
298(7):102119.
PMID: 35691342
The metal-dependent M17 aminopeptidases are conserved throughout all kingdoms of life. This large enzyme family is characterized by a conserved binuclear metal center and a distinctive homohexameric arrangement. Recently, we...
10.
Mandela E, Stubenrauch C, Ryoo D, Hwang H, Cohen E, Torres V, et al.
Elife
. 2022 Jan;
11.
PMID: 35084330
The cell envelope of Gram-negative bacteria consists of two membranes surrounding a periplasm and peptidoglycan layer. Molecular machines spanning the cell envelope depend on spatial constraints and load-bearing forces across...