Terry L Orr-Weaver
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Explore the profile of Terry L Orr-Weaver including associated specialties, affiliations and a list of published articles.
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67
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2456
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Recent Articles
1.
Aviles-Pagan E, Hara M, Orr-Weaver T
Elife
. 2021 Jul;
10.
PMID: 34250903
Control of mRNA translation is a key mechanism by which the differentiated oocyte transitions to a totipotent embryo. In , the PNG kinase complex regulates maternal mRNA translation at the...
2.
Aviles-Pagan E, Kang A, Orr-Weaver T
G3 (Bethesda)
. 2020 Jul;
10(9):2989-2998.
PMID: 32690584
At the oocyte-to-embryo transition the highly differentiated oocyte arrested in meiosis becomes a totipotent embryo capable of embryogenesis. Oocyte maturation (release of the prophase I primary arrest) and egg activation...
3.
Kwasnieski J, Orr-Weaver T, Bartel D
Genome Res
. 2019 Jun;
29(7):1188-1197.
PMID: 31235656
Control of metazoan embryogenesis shifts from maternal to zygotic gene products as the zygotic genome becomes transcriptionally activated. In , zygotic genome activation (ZGA) has been thought to occur in...
4.
Hua B, Bell G, Kashevsky H, Von Stetina J, Orr-Weaver T
BMC Genomics
. 2018 Aug;
19(1):623.
PMID: 30134926
Background: Genomic regions repressed for DNA replication, resulting in either delayed replication in S phase or underreplication in polyploid cells, are thought to be controlled by inhibition of replication origin...
5.
Petrova B, Liu K, Tian C, Kitaoka M, Freinkman E, Yang J, et al.
Proc Natl Acad Sci U S A
. 2018 Aug;
115(34):E7978-E7986.
PMID: 30082411
The metabolic and redox state changes during the transition from an arrested oocyte to a totipotent embryo remain uncharacterized. Here, we applied state-of-the-art, integrated methodologies to dissect these changes in...
6.
Hara M, Lourido S, Petrova B, Lou H, Von Stetina J, Kashevsky H, et al.
Elife
. 2018 Feb;
7.
PMID: 29480805
The Drosophila Pan Gu (PNG) kinase complex regulates hundreds of maternal mRNAs that become translationally repressed or activated as the oocyte transitions to an embryo. In a previous paper (Hara...
7.
Aviles-Pagan E, Orr-Weaver T
Semin Cell Dev Biol
. 2018 Feb;
84:100-110.
PMID: 29448071
The transition from oocyte to embryo marks the onset of development. This process requires complex regulation to link developmental signals with profound changes in mRNA translation, cell cycle control, and...
8.
Von Stetina J, Frawley L, Unhavaithaya Y, Orr-Weaver T
Development
. 2018 Feb;
145(3).
PMID: 29440220
Regulation of cell size is crucial in development. In plants and animals two cell cycle variants are employed to generate large cells by increased ploidy: the endocycle and endomitosis. The...
9.
Pinto B, Orr-Weaver T
Proc Natl Acad Sci U S A
. 2017 Nov;
114(49):12988-12993.
PMID: 29158400
Proper segregation of chromosomes in meiosis is essential to prevent miscarriages and birth defects. This requires that sister chromatids maintain cohesion at the centromere as cohesion is released on the...
10.
Hua B, Orr-Weaver T
Genetics
. 2017 Sep;
207(1):29-47.
PMID: 28874453
Proper control of DNA replication is critical to ensure genomic integrity during cell proliferation. In addition, differential regulation of the DNA replication program during development can change gene copy number...