David M MacAlpine
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Explore the profile of David M MacAlpine including associated specialties, affiliations and a list of published articles.
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55
Citations
5243
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Recent Articles
1.
Moyung K, Li Y, Hartemink A, MacAlpine D
bioRxiv
. 2024 Jun;
PMID: 38826400
Epigenetic mechanisms contribute to gene regulation by altering chromatin accessibility through changes in transcription factor (TF) and nucleosome occupancy throughout the genome. Despite numerous studies focusing on changes in gene...
2.
Chen B, MacAlpine H, Hartemink A, MacAlpine D
Genome Res
. 2023 Dec;
33(12):2108-2118.
PMID: 38081658
Proper maintenance of epigenetic information after replication is dependent on the rapid assembly and maturation of chromatin. Chromatin Assembly Complex 1 (CAF-1) is a conserved histone chaperone that deposits (H3-H4)...
3.
Chen B, MacAlpine H, Hartemink A, MacAlpine D
bioRxiv
. 2023 Jun;
PMID: 37292814
Proper maintenance of epigenetic information after replication is dependent on the rapid assembly and maturation of chromatin. Chromatin Assembly Complex 1 (CAF-1) is a conserved histone chaperone that deposits (H3-H4)...
4.
Li Y, Hartemink A, MacAlpine D
Genes (Basel)
. 2021 Dec;
12(12).
PMID: 34946946
Origins of DNA replication are specified by the ordered recruitment of replication factors in a cell-cycle-dependent manner. The assembly of the pre-replicative complex in G1 and the pre-initiation complex prior...
5.
Hoffman R, MacAlpine H, MacAlpine D
Genes Dev
. 2021 Sep;
35(19-20):1339-1355.
PMID: 34556529
Prior to initiation of DNA replication, the eukaryotic helicase, Mcm2-7, must be activated to unwind DNA at replication start sites in early S phase. To study helicase activation within origin...
6.
Mitra S, Zhong J, MacAlpine D, Hartemink A
Res Comput Mol Biol
. 2021 Aug;
12074:136-151.
PMID: 34386808
Chromatin is the tightly packaged structure of DNA and protein within the nucleus of a cell. The arrangement of different protein complexes along the DNA modulates and is modulated by...
7.
MacAlpine D
Mol Cell
. 2021 Jul;
81(14):2873-2874.
PMID: 34270943
Wang et al. (2021) comprehensively map DNA replication initiation events across the human genome using single-molecule optical resolution mapping and find that initiation events are randomly distributed across broad initiation...
8.
Mitra S, Zhong J, Tran T, MacAlpine D, Hartemink A
Nucleic Acids Res
. 2021 Jul;
49(14):7925-7938.
PMID: 34255854
Chromatin is a tightly packaged structure of DNA and protein within the nucleus of a cell. The arrangement of different protein complexes along the DNA modulates and is modulated by...
9.
Tran T, MacAlpine H, Tripuraneni V, Mitra S, MacAlpine D, Hartemink A
Genome Res
. 2021 Apr;
31(6):1035-1046.
PMID: 33893157
Though the sequence of the genome within each eukaryotic cell is essentially fixed, it exists within a complex and changing chromatin state. This state is determined, in part, by the...
10.
Tripuraneni V, Memisoglu G, MacAlpine H, Tran T, Zhu W, Hartemink A, et al.
Genome Res
. 2021 Apr;
31(5):775-788.
PMID: 33811083
We interrogated at nucleotide resolution the spatiotemporal order of chromatin changes that occur immediately following a site-specific double-strand break (DSB) upstream of the locus and its subsequent repair by nonhomologous...