Terence K Lee
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Explore the profile of Terence K Lee including associated specialties, affiliations and a list of published articles.
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44
Citations
1880
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Recent Articles
1.
Man K, Zhou L, Yu H, Lam K, Cheng W, Yu J, et al.
Nat Commun
. 2023 Nov;
14(1):7863.
PMID: 38030644
Tumor lineage plasticity, considered a hallmark of cancer, denotes the phenomenon in which tumor cells co-opt developmental pathways to attain cellular plasticity, enabling them to evade targeted therapeutic interventions. However,...
2.
Yu H, Zhou L, Loong J, Lam K, Wong T, Ng K, et al.
Hepatology
. 2023 Jan;
78(6):1711-1726.
PMID: 36630996
Background And Aims: HCC is an aggressive disease with poor clinical outcome. Understanding the mechanisms that drive cancer stemness, which we now know is the root cause of therapy failure...
3.
Wong T, Wong T, Zhou L, Man K, Purcell J, Lee T, et al.
Cell Mol Gastroenterol Hepatol
. 2022 Oct;
15(1):13-37.
PMID: 36202326
Background & Aims: Metastasis is found in most advanced hepatocellular carcinoma (HCC) patients, and it drives tumor recurrence and systemic failure. There is no effective treatment owing to its complex...
4.
Loh J, Li T, Zhou L, Wong T, Liu X, Ma V, et al.
Cancer Res
. 2021 Sep;
81(22):5692-5705.
PMID: 34551961
The tumor microenvironment plays a critical role in maintaining the immature phenotype of tumor-initiating cells (TIC) to promote cancer. Hepatocellular carcinoma (HCC) is a unique disease in that it develops...
5.
Leung H, Leung C, Lau E, Chung K, Mok E, Lei M, et al.
Cancer Res
. 2021 Apr;
81(12):3229-3240.
PMID: 33903122
The survival benefit derived from sorafenib treatment for patients with hepatocellular carcinoma (HCC) is modest due to acquired resistance. Targeting cancer stem cells (CSC) is a possible way to reverse...
6.
Loong J, Wong T, Tong M, Sharma R, Zhou L, Ng K, et al.
J Clin Invest
. 2021 Apr;
131(11).
PMID: 33878034
Rapidly growing tumors often experience hypoxia and nutrient (e.g., glucose) deficiency because of poor vascularization. Tumor cells respond to the cytotoxic effects of such stresses by inducing molecular adaptations that...
7.
Ng K, Shea Q, Wong T, Luk S, Tong M, Lo C, et al.
Adv Sci (Weinh)
. 2021 Mar;
8(5):2002483.
PMID: 33717837
The physical microenvironment is a critical mediator of tumor behavior. However, detailed biological and mechanistic insight is lacking. The present study reveals the role of chemotherapy-enriched CD133+ liver cancer stem...
8.
Che N, Ng K, Wong T, Tong M, Kau P, Chan L, et al.
Cancer Lett
. 2020 Nov;
501:247-262.
PMID: 33186656
Autophagy is a critical survival factor for cancer cells, whereby it maintains cellular homeostasis by degrading damaged organelles and unwanted proteins and supports cellular biosynthesis in response to stress. Cancer...
9.
Luk S, Ng K, Zhou L, Tong M, Wong T, Yu H, et al.
Hepatology
. 2019 Nov;
72(1):183-197.
PMID: 31680287
Background And Aims: Embryonic stem-cell-related transcription factors are central to the establishment and maintenance of stemness and pluripotency, and their altered expression plays key roles in tumors, including hepatocellular carcinoma...
10.
Wong T, Ng K, Tan K, Chan L, Zhou L, Che N, et al.
Hepatology
. 2019 Aug;
71(4):1279-1296.
PMID: 31469916
Background And Aims: Most tumor cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and promote tumorigenicity and drug resistance. Intriguingly, the molecular mechanisms underlying this phenomenon are...