Teija Parkkari
Overview
Explore the profile of Teija Parkkari including associated specialties, affiliations and a list of published articles.
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29
Citations
290
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Recent Articles
1.
Heikkinen T, Bragge T, Kuosmanen J, Parkkari T, Gustafsson S, Kwan M, et al.
PLoS One
. 2021 Oct;
16(10):e0258486.
PMID: 34648564
Huntington's disease (HD) results from an expansion mutation in the polyglutamine tract in huntingtin. Although huntingtin is ubiquitously expressed in the body, the striatum suffers the most severe pathology. Rhes...
2.
Heikkinen T, Bragge T, Bhattarai N, Parkkari T, Puolivali J, Kontkanen O, et al.
PLoS One
. 2020 Dec;
15(12):e0243052.
PMID: 33370315
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by severe disruption of cognitive and motor functions, including changes in posture and gait. A number of HD mouse models have...
3.
Huhtala T, Poutiainen P, Rytkonen J, Lehtimaki K, Parkkari T, Kasanen I, et al.
EJNMMI Radiopharm Chem
. 2019 Oct;
4(1):20.
PMID: 31659519
Purpose: Dopamine receptors are involved in pathophysiology of neuropsychiatric diseases, including Huntington's disease (HD). PET imaging of dopamine D2 receptors (D2R) in HD patients has demonstrated 40% decrease in D2R...
4.
Piiponniemi T, Parkkari T, Heikkinen T, Puolivali J, Park L, Cachope R, et al.
Front Behav Neurosci
. 2018 Oct;
12:226.
PMID: 30333735
Cognitive disturbances often predate characteristic motor dysfunction in individuals with Huntington's disease (HD) and place an increasing burden on the HD patients and caregivers with the progression of the disorder....
5.
Aaltonen N, Kedzierska E, Orzelska-Gorka J, Lehtonen M, Navia-Paldanius D, Jakupovic H, et al.
J Pharmacol Exp Ther
. 2016 Jul;
359(1):62-72.
PMID: 27451409
Monoacylglycerol lipase (MAGL) is a serine hydrolase that acts as a principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG). In addition to terminating the signaling function of 2-AG, MAGL liberates...
6.
Yrjola S, Parkkari T, Navia-Paldanius D, Laitinen T, Kaczor A, Kokkola T, et al.
Eur J Med Chem
. 2015 Nov;
107:119-32.
PMID: 26575458
To date, many known G protein-coupled receptor 55 (GPR55) ligands are those identified among the cannabinoids. In order to further study the function of GPR55, new potent and selective ligands...
7.
Kaczor A, Targowska-Duda K, Patel J, Laitinen T, Parkkari T, Adams Y, et al.
J Mol Model
. 2015 Sep;
21(10):250.
PMID: 26350245
The endocannabinoid system remains an attractive molecular target for pharmacological intervention due to its roles in the central nervous system in learning, thinking, emotional function, regulation of food intake or...
8.
Patel J, van Bruchem J, Laitinen T, Kaczor A, Navia-Paldanius D, Parkkari T, et al.
Bioorg Med Chem
. 2015 Sep;
23(19):6335-45.
PMID: 26344596
This article describes our systematic approach to exploring the utility of the 1,3,4-oxadiazol-2-one scaffold in the development of ABHD6 inhibitors. Compound 3-(3-aminobenzyl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one (JZP-169, 52) was identified as a potent inhibitor...
9.
Manera C, Malfitano A, Parkkari T, Lucchesi V, Carpi S, Fogli S, et al.
Eur J Med Chem
. 2015 May;
97:10-8.
PMID: 25935384
Several recent studies suggest that selective CB2 receptor agonists may represent a valid pharmacological approach in the treatment of various diseases due to the absence of relevant psychoactive side effect....
10.
Liin S, Ejneby M, Barro-Soria R, Skarsfeldt M, Larsson J, Starck Harlin F, et al.
Proc Natl Acad Sci U S A
. 2015 Apr;
112(18):5714-9.
PMID: 25901329
Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the β-subunit KCNE1 form the cardiac IKs channel that is central for cardiac repolarization. In this study, we explore the prospects...