Ted Sharpe
Overview
Explore the profile of Ted Sharpe including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
8519
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0
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Recent Articles
1.
Hayes T, Aquilanti E, Persky N, Yang X, Kim E, Brenan L, et al.
Nat Commun
. 2024 Apr;
15(1):3273.
PMID: 38627431
No abstract available.
2.
Hayes T, Aquilanti E, Persky N, Yang X, Kim E, Brenan L, et al.
Nat Commun
. 2024 Mar;
15(1):2742.
PMID: 38548752
The epidermal growth factor receptor, EGFR, is frequently activated in lung cancer and glioblastoma by genomic alterations including missense mutations. The different mutation spectra in these diseases are reflected in...
3.
Collins R, Brand H, Karczewski K, Zhao X, Alfoldi J, Francioli L, et al.
Nature
. 2021 Feb;
590(7846):E55.
PMID: 33536627
No abstract available.
4.
Collins R, Brand H, Karczewski K, Zhao X, Alfoldi J, Francioli L, et al.
Nature
. 2020 May;
581(7809):444-451.
PMID: 32461652
Structural variants (SVs) rearrange large segments of DNA and can have profound consequences in evolution and human disease. As national biobanks, disease-association studies, and clinical genetic testing have grown increasingly...
5.
Giacomelli A, Yang X, Lintner R, McFarland J, Duby M, Kim J, et al.
Nat Genet
. 2018 Sep;
50(10):1381-1387.
PMID: 30224644
Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein p53 (TP53) are missense mutations. Mutant p53 protein is often abundantly expressed in cancers and specific allelic...
6.
Walker M, Pedamallu C, Ojesina A, Bullman S, Sharpe T, Whelan C, et al.
Bioinformatics
. 2018 Jul;
34(24):4287-4289.
PMID: 29982281
Summary: We present an updated version of our computational pipeline, PathSeq, for the discovery and identification of microbial sequences in genomic and transcriptomic libraries from eukaryotic hosts. This pipeline is...
7.
Wala J, Bandopadhayay P, Greenwald N, ORourke R, Sharpe T, Stewart C, et al.
Genome Res
. 2018 Mar;
28(4):581-591.
PMID: 29535149
Structural variants (SVs), including small insertion and deletion variants (indels), are challenging to detect through standard alignment-based variant calling methods. Sequence assembly offers a powerful approach to identifying SVs, but...
8.
Majithia A, Tsuda B, Agostini M, Gnanapradeepan K, Rice R, Peloso G, et al.
Nat Genet
. 2016 Nov;
48(12):1570-1575.
PMID: 27749844
Clinical exome sequencing routinely identifies missense variants in disease-related genes, but functional characterization is rarely undertaken, leading to diagnostic uncertainty. For example, mutations in PPARG cause Mendelian lipodystrophy and increase...
9.
Weisenfeld N, Yin S, Sharpe T, Lau B, Hegarty R, Holmes L, et al.
Nat Genet
. 2014 Oct;
46(12):1350-5.
PMID: 25326702
Complete knowledge of the genetic variation in individual human genomes is a crucial foundation for understanding the etiology of disease. Genetic variation is typically characterized by sequencing individual genomes and...
10.
Brawand D, Wagner C, Li Y, Malinsky M, Keller I, Fan S, et al.
Nature
. 2014 Sep;
513(7518):375-381.
PMID: 25186727
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic diversity, we sequenced the...