David B Jaffe
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Explore the profile of David B Jaffe including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Hurtado J, Rogers T, Jaffe D, Adams B, Bangaru S, Garcia E, et al.
Cell Rep
. 2024 Jun;
43(6):114307.
PMID: 38848216
The development of vaccines and therapeutics that are broadly effective against known and emergent coronaviruses is an urgent priority. We screened the circulating B cell repertoires of COVID-19 survivors and...
2.
Hurtado J, Rogers T, Jaffe D, Adams B, Bangaru S, Garcia E, et al.
bioRxiv
. 2023 Apr;
PMID: 37034676
Development of vaccines and therapeutics that are broadly effective against known and emergent coronaviruses is an urgent priority. Current strategies for developing pan-coronavirus countermeasures have largely focused on the receptor...
3.
Hao H, Ramli R, Wang C, Liu C, Shah S, Mullen P, et al.
PLoS Biol
. 2023 Jan;
21(1):e3001958.
PMID: 36603052
Accumulating observations suggest that peripheral somatosensory ganglia may regulate nociceptive transmission, yet direct evidence is sparse. Here, in experiments on rats and mice, we show that the peripheral afferent nociceptive...
4.
Jaffe D, Shahi P, Adams B, Chrisman A, Finnegan P, Raman N, et al.
Nature
. 2022 Oct;
611(7935):352-357.
PMID: 36289331
The vertebrate adaptive immune system modifies the genome of individual B cells to encode antibodies that bind particular antigens. In most mammals, antibodies are composed of heavy and light chains...
5.
Weisenfeld N, Kumar V, Shah P, Church D, Jaffe D
Genome Res
. 2018 Apr;
28(4):606.1.
PMID: 29610250
No abstract available.
6.
Jaffe D, Brenner R
J Neurophysiol
. 2018 Jan;
119(4):1506-1520.
PMID: 29357445
The gain of a neuron, the number and frequency of action potentials triggered in response to a given amount of depolarizing injection, is an important behavior underlying a neuron's function....
7.
Whitmire L, Ling L, Bugay V, Carver C, Timilsina S, Chuang H, et al.
PLoS One
. 2017 Nov;
12(11):e0188064.
PMID: 29145442
A major challenge is to understand maladaptive changes in ion channels that sets neurons on a course towards epilepsy development. Voltage- and calcium-activated K+ (BK) channels contribute to early spike...
8.
Weisenfeld N, Kumar V, Shah P, Church D, Jaffe D
Genome Res
. 2017 Apr;
27(5):757-767.
PMID: 28381613
Determining the genome sequence of an organism is challenging, yet fundamental to understanding its biology. Over the past decade, thousands of human genomes have been sequenced, contributing deeply to biomedical...
9.
Du X, Hao H, Yang Y, Huang S, Wang C, Gigout S, et al.
J Clin Invest
. 2017 Apr;
127(5):1741-1756.
PMID: 28375159
The integration of somatosensory information is generally assumed to be a function of the central nervous system (CNS). Here we describe fully functional GABAergic communication within rodent peripheral sensory ganglia...
10.
Wang B, Bugay V, Ling L, Chuang H, Jaffe D, Brenner R
J Neurophysiol
. 2016 May;
116(2):456-65.
PMID: 27146987
BK channels are large-conductance calcium- and voltage-activated potassium channels with diverse properties. Knockout of the accessory BK β4-subunit in hippocampus dentate gyrus granule neurons causes BK channels to change properties...