Taushif Khan
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Explore the profile of Taushif Khan including associated specialties, affiliations and a list of published articles.
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46
Citations
2217
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Recent Articles
11.
Guerin A, Moncada-Velez M, Jackson K, Ogishi M, Rosain J, Mancini M, et al.
J Exp Med
. 2024 Apr;
221(5).
PMID: 38557723
CD4+ T cells are vital for host defense and immune regulation. However, the fundamental role of CD4 itself remains enigmatic. We report seven patients aged 5-61 years from five families...
12.
Materna M, Delmonte O, Bosticardo M, Momenilandi M, Conrey P, Charmeteau-De Muylder B, et al.
Science
. 2024 Feb;
383(6686):eadh4059.
PMID: 38422122
We describe humans with rare biallelic loss-of-function variants impairing pre-α T cell receptor (pre-TCRα) expression. Low circulating naive αβ T cell counts at birth persisted over time, with normal memory...
13.
Rosain J, Kiykim A, Michev A, Kendir-Demirkol Y, Rinchai D, Peel J, et al.
J Clin Immunol
. 2024 Feb;
44(3):62.
PMID: 38363432
Purpose: Inborn errors of IFN-γ immunity underlie Mendelian susceptibility to mycobacterial disease (MSMD). Twenty-two genes with products involved in the production of, or response to, IFN-γ and variants of which...
14.
Neehus A, Carey B, Landekic M, Panikulam P, Deutsch G, Ogishi M, et al.
Cell
. 2023 Dec;
187(2):390-408.e23.
PMID: 38157855
We describe a human lung disease caused by autosomal recessive, complete deficiency of the monocyte chemokine receptor C-C motif chemokine receptor 2 (CCR2). Nine children from five independent kindreds have...
15.
Benezech S, Khoryati L, Cognard J, Netea S, Khan T, Moreews M, et al.
N Engl J Med
. 2023 Dec;
389(22):2105-2107.
PMID: 38048195
No abstract available.
16.
Bohlen J, Zhou Q, Philippot Q, Ogishi M, Rinchai D, Nieminen T, et al.
Cell
. 2023 Oct;
186(23):5114-5134.e27.
PMID: 37875108
Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with mycobacterial disease from kindreds of different ancestries (from China, Finland,...
17.
Toufiq M, Rinchai D, Bettacchioli E, Kabeer B, Khan T, Subba B, et al.
J Transl Med
. 2023 Oct;
21(1):728.
PMID: 37845713
Background: Feature selection is a critical step for translating advances afforded by systems-scale molecular profiling into actionable clinical insights. While data-driven methods are commonly utilized for selecting candidate genes, knowledge-driven...
18.
Khan T, Ledoux I, Aziz F, Al Ali F, Chin-Smith E, Ata M, et al.
J Allergy Clin Immunol Glob
. 2023 Oct;
2(3):100117.
PMID: 37779520
Background: Allergic disorders are the consequence of IgE sensitization to allergens. Population studies have shown that certain human leukocyte antigen (HLA) alleles are associated with increased or decreased risk of...
19.
Philippot Q, Ogishi M, Bohlen J, Puchan J, Arias A, Nguyen T, et al.
Sci Immunol
. 2023 Feb;
8(80):eabq5204.
PMID: 36763636
Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less commonly, chronic mucocutaneous candidiasis (CMC) due to...
20.
Rosain J, Neehus A, Manry J, Yang R, Le Pen J, Daher W, et al.
Cell
. 2023 Feb;
186(3):621-645.e33.
PMID: 36736301
Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1. We...