Tatsunori Nishimura
Overview
Explore the profile of Tatsunori Nishimura including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
386
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Recent Articles
1.
Rojas-Chaverra N, Imamura R, Sato H, Passioura T, Mihara E, Nishimura T, et al.
iScience
. 2024 Aug;
27(8):110426.
PMID: 39108737
The regenerative functions associated with cytokines and growth factors have immense therapeutic potential; however, their poor pharmacokinetics, resulting from structural features, hinder their effectiveness. In this study, we aimed to...
2.
Li M, Nishimura T, Takeuchi Y, Hongu T, Wang Y, Shiokawa D, et al.
J Clin Invest
. 2023 Nov;
133(22).
PMID: 37966117
The heterogeneity of cancer stem cells (CSCs) within tumors presents a challenge in therapeutic targeting. To decipher the cellular plasticity that fuels phenotypic heterogeneity, we undertook single-cell transcriptomics analysis in...
3.
Suzuki M, Iijima K, Ogami K, Shinjo K, Murofushi Y, Xie J, et al.
Nat Commun
. 2023 Aug;
14(1):4521.
PMID: 37607907
Oncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop formation are known to impede S phase progression. Nonetheless, cancer cells continuously proliferate under such high-stressed conditions through incompletely understood mechanisms....
4.
Wang Y, Hongu T, Nishimura T, Takeuchi Y, Takano H, Daikoku T, et al.
Biochem Biophys Res Commun
. 2023 Jul;
674:183-189.
PMID: 37450958
Mitochondrial one-carbon metabolism is crucial for embryonic development and tumorigenesis, as it supplies one-carbon units necessary for nucleotide synthesis and rapid cell proliferation. However, its contribution to adult tissue homeostasis...
5.
Lee J, Chen X, Wang Y, Nishimura T, Li M, Ishikawa S, et al.
Biochem Biophys Res Commun
. 2021 Nov;
584:7-14.
PMID: 34753066
Patients with triple-negative breast cancer have a poor prognosis as only a few efficient targeted therapies are available. Cancer cells are characterized by their unregulated proliferation and require large amounts...
6.
Takeuchi Y, Kimura N, Murayama T, Machida Y, Iejima D, Nishimura T, et al.
Proc Natl Acad Sci U S A
. 2021 Oct;
118(43).
PMID: 34663724
Although it is held that proinflammatory changes precede the onset of breast cancer, the underlying mechanisms remain obscure. Here, we demonstrate that FRS2β, an adaptor protein expressed in a small...
7.
Yiming R, Takeuchi Y, Nishimura T, Li M, Wang Y, Meguro-Horike M, et al.
Cancer Sci
. 2021 Jun;
112(9):3810-3821.
PMID: 34145929
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective in patients with non-small-cell lung cancer (NSCLC) harboring EGFR mutations. However, due to acquired resistance to EGFR-TKIs, even patients on...
8.
Baba T, Yoshida T, Tanabe Y, Nishimura T, Morishita S, Gotoh N, et al.
Cell Death Dis
. 2021 Mar;
12(4):322.
PMID: 33771977
Accumulating evidence indicates the presence of cytoplasmic DNAs in various types of malignant cells, and its involvement in anti-cancer drug- or radiotherapy-mediated DNA damage response and replication stress. However, the...
9.
Murayama T, Takeuchi Y, Yamawaki K, Natsume T, Li M, Marcela R, et al.
Cancer Sci
. 2020 Dec;
112(3):1209-1224.
PMID: 33340428
Cancer stem-like cells (CSCs) induce drug resistance and recurrence of tumors when they experience DNA replication stress. However, the mechanisms underlying DNA replication stress in CSCs and its compensation remain...
10.
Yanagi H, Watanabe T, Nishimura T, Hayashi T, Kono S, Tsuchida H, et al.
Cancer Sci
. 2020 Sep;
111(12):4359-4370.
PMID: 32976661
Metastatic progression remains the major cause of death in human breast cancer. Cancer cells with cancer stem cell (CSC) properties drive initiation and growth of metastases at distant sites. We...