Talitha L Kerrigan
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Explore the profile of Talitha L Kerrigan including associated specialties, affiliations and a list of published articles.
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13
Citations
466
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Recent Articles
1.
Imm J, Pishva E, Ali M, Kerrigan T, Jeffries A, Burrage J, et al.
Front Cell Dev Biol
. 2021 Jul;
9:647981.
PMID: 34277599
In development, differentiation from a pluripotent state results in global epigenetic changes, although the extent to which this occurs in induced pluripotent stem cell-based neuronal models has not been extensively...
2.
Stathakos P, Jimenez-Moreno N, Crompton L, Nistor P, Badger J, Barbuti P, et al.
Autophagy
. 2020 Apr;
17(4):855-871.
PMID: 32286126
Macroautophagy/autophagy cytoplasmic quality control pathways are required during neural development and are critical for the maintenance of functional neuronal populations in the adult brain. Robust evidence now exists that declining...
3.
Thei L, Imm J, Kaisis E, Dallas M, Kerrigan T
Front Neurosci
. 2018 Oct;
12:676.
PMID: 30323735
Alzheimer's disease is the most common form of dementia, it is estimated to affect over 40 million people worldwide. Classically, the disease has been characterized by the neuropathological hallmarks of...
4.
Imm J, Kerrigan T, Jeffries A, Lunnon K
Epigenomics
. 2017 Oct;
9(11):1455-1468.
PMID: 28969469
It is thought that both genetic and epigenetic variation play a role in Alzheimer's disease initiation and progression. With the advent of somatic cell reprogramming into induced pluripotent stem cells...
5.
Tamagnini F, Novelia J, Kerrigan T, Brown J, Tsaneva-Atanasova K, Randall A
Front Cell Neurosci
. 2015 Nov;
9:372.
PMID: 26528126
Amyloidopathy involves the accumulation of insoluble amyloid β (Aβ) species in the brain's parenchyma and is a key histopathological hallmark of Alzheimer's disease (AD). Work on transgenic mice that overexpress...
6.
Whitehead G, Jo J, Hogg E, Piers T, Kim D, Seaton G, et al.
Brain
. 2013 Nov;
136(Pt 12):3753-65.
PMID: 24271563
The neuroendocrine response to episodes of acute stress is crucial for survival whereas the prolonged response to chronic stress can be detrimental. Learning and memory are particularly susceptible to stress...
7.
Crompton L, Byrne M, Taylor H, Kerrigan T, Bru-Mercier G, Badger J, et al.
Stem Cell Res
. 2013 Sep;
11(3):1206-21.
PMID: 24013066
Basal forebrain cholinergic neurons (bfCNs) which provide innervation to the hippocampus and cortex, are required for memory and learning, and are primarily affected in Alzheimer's Disease (AD), resulting in related...
8.
Kerrigan T, Randall A
Front Neurol
. 2013 Feb;
4:9.
PMID: 23407382
Alzheimer's disease (AD) is increasingly referred to as a "synaptopathy." This moniker reflects the loss or damage of synapses that occurs as the disease progresses, which in turn produces functional...
9.
Watt N, Taylor D, Kerrigan T, Griffiths H, Rushworth J, Whitehouse I, et al.
Nat Commun
. 2012 Oct;
3:1134.
PMID: 23072804
Zinc is released into the synaptic cleft upon exocytotic stimuli, although the mechanism for its reuptake into neurons is unresolved. Here we show that the cellular prion protein enhances the...
10.
Kerrigan T, Daniel J W, Regan P, Cho K
Front Mol Neurosci
. 2012 May;
5:57.
PMID: 22586365
Neuronal calcium sensors (NCS) readily bind calcium and undergo conformational changes enabling them to interact and regulate specific target molecules. These interactions lead to dynamic alterations in protein trafficking that...