The Role of Neuronal Calcium Sensors in Balancing Synaptic Plasticity and Synaptic Dysfunction

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2012 May 16

PMID 22586365

Citations 7

Authors

Talitha L Kerrigan

Whitcomb Daniel J

Philip L Regan

Kwangwook Cho

Affiliations

Soon will be listed here.

Abstract

Neuronal calcium sensors (NCS) readily bind calcium and undergo conformational changes enabling them to interact and regulate specific target molecules. These interactions lead to dynamic alterations in protein trafficking that significantly impact upon synaptic function. Emerging evidence suggests that NCS and alterations in Ca(2+) mobilization modulate glutamate receptor trafficking, subsequently determining the expression of different forms of synaptic plasticity. In this review, we aim to discuss the functional relevance of NCS in protein trafficking and their emerging role in synaptic plasticity. Their significance within the concept of "translational neuroscience" will also be highlighted, by assessing their potential as key molecules in neurodegeneration.

Citing Articles

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References

Buxbaum J, Choi E, Luo Y, Lilliehook C, Crowley A, Merriam D . Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med. 1998; 4(10):1177-81. DOI: 10.1038/2673. View

Ekinci F, Linsley M, Shea T . Beta-amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation. Brain Res Mol Brain Res. 2000; 76(2):389-95. DOI: 10.1016/s0169-328x(00)00025-5. View

Lisman J . A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. Proc Natl Acad Sci U S A. 1989; 86(23):9574-8. PMC: 298540. DOI: 10.1073/pnas.86.23.9574. View

Citri A, Bhattacharyya S, Ma C, Morishita W, Fang S, Rizo J . Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression. J Neurosci. 2010; 30(49):16437-52. PMC: 3004477. DOI: 10.1523/JNEUROSCI.4478-10.2010. View

Kim M, Futai K, Jo J, Hayashi Y, Cho K, Sheng M . Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95. Neuron. 2007; 56(3):488-502. DOI: 10.1016/j.neuron.2007.09.007. View

Jo J, Whitcomb D, Olsen K, Kerrigan T, Lo S, Bru-Mercier G . Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β. Nat Neurosci. 2011; 14(5):545-7. DOI: 10.1038/nn.2785. View

Jo J, Son G, Winters B, Kim M, Whitcomb D, Dickinson B . Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95. Nat Neurosci. 2010; 13(10):1216-24. DOI: 10.1038/nn.2636. View

Ames J, Ishima R, Tanaka T, Gordon J, Stryer L, Ikura M . Molecular mechanics of calcium-myristoyl switches. Nature. 1997; 389(6647):198-202. DOI: 10.1038/38310. View

Kim J, Anwyl R, Suh Y, Djamgoz M, Rowan M . Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo. J Neurosci. 2001; 21(4):1327-33. PMC: 6762223. View

10.

Berridge M . Neuronal calcium signaling. Neuron. 1998; 21(1):13-26. DOI: 10.1016/s0896-6273(00)80510-3. View

11.

Park H, Varadi A, Seok H, Jo J, Gilpin H, Liew C . mGluR5 is involved in dendrite differentiation and excitatory synaptic transmission in NTERA2 human embryonic carcinoma cell-derived neurons. Neuropharmacology. 2007; 52(6):1403-14. DOI: 10.1016/j.neuropharm.2007.01.021. View

12.

Hanley J, Henley J . PICK1 is a calcium-sensor for NMDA-induced AMPA receptor trafficking. EMBO J. 2005; 24(18):3266-78. PMC: 1224691. DOI: 10.1038/sj.emboj.7600801. View

13.

He Y, Liwo A, Weinstein H, Scheraga H . PDZ binding to the BAR domain of PICK1 is elucidated by coarse-grained molecular dynamics. J Mol Biol. 2010; 405(1):298-314. PMC: 3008210. DOI: 10.1016/j.jmb.2010.10.051. View

14.

Schneider I, Reverse D, Dewachter I, Ris L, Caluwaerts N, Kuiperi C . Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation. J Biol Chem. 2001; 276(15):11539-44. DOI: 10.1074/jbc.M010977200. View

15.

Khachaturian Z . Hypothesis on the regulation of cytosol calcium concentration and the aging brain. Neurobiol Aging. 1987; 8(4):345-6. DOI: 10.1016/0197-4580(87)90073-x. View

16.

Pongs O, Lindemeier J, Zhu X, Theil T, Engelkamp D, Krah-Jentgens I . Frequenin--a novel calcium-binding protein that modulates synaptic efficacy in the Drosophila nervous system. Neuron. 1993; 11(1):15-28. DOI: 10.1016/0896-6273(93)90267-u. View

17.

Paterlini M, Revilla V, Grant A, Wisden W . Expression of the neuronal calcium sensor protein family in the rat brain. Neuroscience. 2000; 99(2):205-16. DOI: 10.1016/s0306-4522(00)00201-3. View

18.

Xia J, Chung H, Wihler C, Huganir R, Linden D . Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins. Neuron. 2001; 28(2):499-510. DOI: 10.1016/s0896-6273(00)00128-8. View

19.

Burgoyne R, Haynes L . Understanding the physiological roles of the neuronal calcium sensor proteins. Mol Brain. 2012; 5(1):2. PMC: 3271974. DOI: 10.1186/1756-6606-5-2. View

20.

Burgoyne R . Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling. Nat Rev Neurosci. 2007; 8(3):182-93. PMC: 1887812. DOI: 10.1038/nrn2093. View