Lucy A Crompton
Overview
Explore the profile of Lucy A Crompton including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
348
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Recent Articles
1.
McComish S, OSullivan J, Copas A, Imiolek M, Boyle N, Crompton L, et al.
Exp Neurol
. 2024 Oct;
382:114979.
PMID: 39357593
Astrocytes are the most abundant type of glial cell in the central nervous system and they play pivotal roles in both normal health and disease. Their dysfunction is detrimental to...
2.
Targett I, Crompton L, Conway M, Craig T
In Vitro Cell Dev Biol Anim
. 2024 Jul;
60(9):1058-1067.
PMID: 39017752
There has been much interest in the use of cell culture models of neurones, to avoid the animal welfare and cost issues of using primary and human-induced pluripotent stem cell...
3.
Crompton L, McComish S, Steward T, Whitcomb D, Lane J, Caldwell M
Brain Commun
. 2023 May;
5(2):fcad114.
PMID: 37124945
This scientific commentary refers to 'Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles', by Clarke (https://doi.org/10.1093/brain/awaa258) in Brain.
4.
Crompton L, McComish S, Stathakos P, Cordero-Llana O, Lane J, Caldwell M
J Vis Exp
. 2021 Oct;
(176).
PMID: 34661566
In Parkinson's disease, progressive dysfunction and degeneration of dopamine neurons in the ventral midbrain cause life-changing symptoms. Neuronal degeneration has diverse causes in Parkinson's, including non-cell autonomous mechanisms mediated by...
5.
Stathakos P, Jimenez-Moreno N, Crompton L, Nistor P, Badger J, Barbuti P, et al.
Autophagy
. 2020 Apr;
17(4):855-871.
PMID: 32286126
Macroautophagy/autophagy cytoplasmic quality control pathways are required during neural development and are critical for the maintenance of functional neuronal populations in the adult brain. Robust evidence now exists that declining...
6.
Hawkins S, Crompton L, Sood A, Saunders M, Boyle N, Buckley A, et al.
Nat Nanotechnol
. 2018 Apr;
13(5):427-433.
PMID: 29610530
The potential for maternal nanoparticle (NP) exposures to cause developmental toxicity in the fetus without the direct passage of NPs has previously been shown, but the mechanism remained elusive. We...
7.
Crompton L, Cordero-Llana O, Caldwell M
Brain Pathol
. 2017 Jun;
27(4):530-544.
PMID: 28585380
Neuroscience and Neurobiology have historically been neuron biased, yet up to 40% of the cells in the brain are astrocytes. These cells are heterogeneous and regionally diverse but universally essential...
8.
Crompton L, Byrne M, Taylor H, Kerrigan T, Bru-Mercier G, Badger J, et al.
Stem Cell Res
. 2013 Sep;
11(3):1206-21.
PMID: 24013066
Basal forebrain cholinergic neurons (bfCNs) which provide innervation to the hippocampus and cortex, are required for memory and learning, and are primarily affected in Alzheimer's Disease (AD), resulting in related...
9.
Trichas G, Joyce B, Crompton L, Wilkins V, Clements M, Tada M, et al.
PLoS Biol
. 2011 Mar;
9(2):e1001019.
PMID: 21364967
The anterior visceral endoderm (AVE), a signalling centre within the simple epithelium of the visceral endoderm (VE), is required for anterior-posterior axis specification in the mouse embryo. AVE cells migrate...
10.
Cogan N, Baird D, Phillips R, Crompton L, Caldwell M, Rubio M, et al.
Mutat Res
. 2009 Oct;
683(1-2):1-8.
PMID: 19800897
The bystander effect is a feature of low dose radiation exposure and is characterized by a signaling process from irradiated cells to non irradiated cells, which causes DNA and chromosome...