T N Seyfried
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Explore the profile of T N Seyfried including associated specialties, affiliations and a list of published articles.
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94
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1468
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Recent Articles
1.
Seyfried T, Choi H, Chevalier A, Hogan D, Akgoc Z, Schneider J
ASN Neuro
. 2018 Jun;
10:1759091418781889.
PMID: 29932343
Parkinson's disease (PD) is a neurodegenerative movement disorder involving the selective loss of dopamine-producing neurons in the substantia nigra (SN). Differences in disease presentation, prevalence, and age of onset have...
2.
Poff A, Ward N, Seyfried T, Arnold P, DAgostino D
PLoS One
. 2015 Jun;
10(6):e0127407.
PMID: 26061868
The Warburg effect and tumor hypoxia underlie a unique cancer metabolic phenotype characterized by glucose dependency and aerobic fermentation. We previously showed that two non-toxic metabolic therapies - the ketogenic...
3.
McCurdy V, Rockwell H, Arthur J, Bradbury A, Johnson A, Randle A, et al.
Gene Ther
. 2014 Dec;
22(2):181-9.
PMID: 25474439
Sandhoff disease (SD) is caused by deficiency of N-acetyl-β-hexosaminidase (Hex) resulting in pathological accumulation of GM2 ganglioside in lysosomes of the central nervous system (CNS) and progressive neurodegeneration. Currently, there...
4.
Poff A, Ari C, Arnold P, Seyfried T, DAgostino D
Int J Cancer
. 2014 Mar;
135(7):1711-20.
PMID: 24615175
Cancer cells express an abnormal metabolism characterized by increased glucose consumption owing to genetic mutations and mitochondrial dysfunction. Previous studies indicate that unlike healthy tissues, cancer cells are unable to...
5.
Arthur J, Lee J, Snyder E, Seyfried T
Neurochem Res
. 2012 Feb;
37(6):1335-43.
PMID: 22367451
Sandhoff Disease (SD) involves the CNS accumulation of ganglioside GM2 and asialo-GM2 (GA2) due to inherited defects in the β-subunit gene of β-hexosaminidase A and B (Hexb gene). Substrate reduction...
6.
Broekman M, Baek R, Comer L, Fernandez J, Seyfried T, Sena-Esteves M
Mol Ther
. 2006 Dec;
15(1):30-7.
PMID: 17164772
GM1-gangliosidosis is a glycosphingolipid (GSL) lysosomal storage disease caused by autosomal recessive deficiency of lysosomal acid beta-galactosidase (betagal), and characterized by accumulation of GM1-ganglioside and GA1 in the brain. Here...
7.
Todorova M, Mantis J, Le M, Kim C, Seyfried T
Genes Brain Behav
. 2006 Oct;
5(7):518-27.
PMID: 17010098
Gene identification has progressed rapidly for monogenic epilepsies, but complex gene-environmental interactions have hindered progress in gene identification for multifactorial epilepsies. We analyzed the role of environmental risk factors in...
8.
Kasperzyk J, dAzzo A, Platt F, Alroy J, Seyfried T
J Lipid Res
. 2005 Feb;
46(4):744-51.
PMID: 15687347
II3NeuAc-GgOse4Cer (GM1) gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid beta-galactosidase (beta-gal), resulting in the accumulation of ganglioside GM1 and its asialo derivative GgOse4Cer (GA1)...
9.
Seyfried T, Sanderson T, El-Abbadi M, McGowan R, Mukherjee P
Br J Cancer
. 2003 Oct;
89(7):1375-82.
PMID: 14520474
Brain tumours lack metabolic versatility and are dependent largely on glucose for energy. This contrasts with normal brain tissue that can derive energy from both glucose and ketone bodies. We...
10.
Mukherjee P, El-Abbadi M, Kasperzyk J, Ranes M, Seyfried T
Br J Cancer
. 2002 Jun;
86(10):1615-21.
PMID: 12085212
Diet and lifestyle produce major effects on tumour incidence, prevalence, and natural history. Moderate dietary restriction has long been recognised as a natural therapy that improves health, promotes longevity, and...