T Michael Underhill
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Explore the profile of T Michael Underhill including associated specialties, affiliations and a list of published articles.
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74
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2346
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Recent Articles
1.
Bernier L, Hefendehl J, Scott R, Tung L, Lewis C, Soliman H, et al.
Nat Neurosci
. 2025 Feb;
28(3):517-535.
PMID: 39962273
Functional revascularization is key to stroke recovery and requires remodeling and regeneration of blood vessels around which is located the brain's only stromal compartment. Stromal progenitor cells (SPCs) are critical...
2.
Wiens M, Farahani H, Scott R, Underhill T, Bashashati A
Genome Res
. 2024 Aug;
34(8):1196-1210.
PMID: 39147582
Single-cell sequencing methodologies such as scRNA-seq and scATAC-seq have become widespread and effective tools to interrogate tissue composition. Increasingly, variant callers are being applied to these methodologies to resolve the...
3.
Hofvander J, Qiu A, Lee K, Bilenky M, Carles A, Cao Q, et al.
bioRxiv
. 2024 May;
PMID: 38798672
Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy characterized by a pathognomonic chromosomal translocation leading to the formation of the SS18::SSX fusion oncoprotein. SS18::SSX associates with mammalian BAF complexes suggesting...
4.
Bastedo W, Scott R, Arostegui M, Underhill T
Fluids Barriers CNS
. 2024 Apr;
21(1):31.
PMID: 38575991
Background: In the choroid plexus and pituitary gland, vasculature is known to have a permeable, fenestrated phenotype which allows for the free passage of molecules in contrast to the blood...
5.
Benabdallah N, Dalal V, Scott R, Marcous F, Sotiriou A, Kommoss F, et al.
Nat Struct Mol Biol
. 2023 Sep;
30(11):1640-1652.
PMID: 37735617
The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 (PRC1) target genes. Here we show...
6.
Lotto J, Cullum R, Drissler S, Arostegui M, Garside V, Fuglerud B, et al.
Nat Commun
. 2023 Sep;
14(1):5567.
PMID: 37689753
Epithelial-to-mesenchymal transitions (EMTs) of both endocardium and epicardium guide atrioventricular heart valve formation, but the cellular complexity and small scale of this tissue have restricted analyses. To circumvent these issues,...
7.
Wang Y, Chen S, Ta M, Senz J, Tao L, Thornton S, et al.
Cancer Res
. 2023 Jul;
83(21):3517-3528.
PMID: 37494476
Significance: Generation of a Dicer1 mutant mouse model establishes the oncogenicity of missense mutations in the DICER1 RNase IIIb domain and provides a faithful model of DICER1 syndrome-associated cancer for...
8.
Exogenously delivered iPSCs disrupt the natural repair response of endogenous MPCs after bone injury
Ferrie L, Premnath P, Olsen A, Larijani L, Besler B, Rancourt D, et al.
Sci Rep
. 2023 Jun;
13(1):9378.
PMID: 37296277
Promoting bone healing including fracture non-unions are promising targets for bone tissue engineering due to the limited success of current clinical treatment methods. There has been significant research on the...
9.
Arostegui M, Scott R, Underhill T
Cell Rep
. 2023 Apr;
42(4):112325.
PMID: 37002923
The musculoskeletal system relies on the integration of multiple components with diverse physical properties, such as striated muscle, tendon, and bone, that enable locomotion and structural stability. This relies on...
10.
Arostegui M, Scott R, Bose K, Underhill T
Nat Commun
. 2022 Aug;
13(1):4989.
PMID: 36008423
Tissue development and regeneration rely on the cooperation of multiple mesenchymal progenitor (MP) subpopulations. We recently identified Hic1 as a marker of quiescent MPs in multiple adult tissues. Here, we...