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Frank Beier

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Articles 144
Citations 4164
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Recent Articles
1.
Schulz J, Birmingham T, Philpott H, Appleton C, Atkinson H, Giffin J, et al.
Arthritis Res Ther . 2024 Oct; 26(1):176. PMID: 39390512
Background: Mechanobiological mechanisms of osteoarthritis (OA) are unclear. Our objectives were to explore: 1) changes in knee joint physiology using a large panel of synovial fluid biomarkers from before to...
2.
Wakefield B, Tang J, Hutchinson J, Kanji R, Brooks C, Grol M, et al.
J Orthop Res . 2024 Mar; 42(8):1696-1709. PMID: 38499500
Pannexin 3 (Panx3) is a glycoprotein that forms mechanosensitive channels expressed in chondrocytes and annulus fibrosus cells of the intervertebral disc (IVD). Evidence suggests Panx3 plays contrasting roles in traumatic...
3.
Wolpe A, Luse M, Baryiames C, Schug W, Wolpe J, Johnstone S, et al.
Sci Signal . 2024 Jan; 17(821):eadg2622. PMID: 38289985
Targeted degradation regulates the activity of the transcriptional repressor Bcl6 and its ability to suppress oxidative stress and inflammation. Here, we report that abundance of endothelial Bcl6 is determined by...
4.
Hutchinson J, Veras M, Serjeant M, McCann M, Kelly A, Quinonez D, et al.
JOR Spine . 2023 Dec; 6(4):e1298. PMID: 38156059
Background: Intervertebral disc (IVD) degeneration is a major contributor to back pain and disability. The cause of IVD degeneration is multifactorial, with no disease-modifying treatments. Mouse models are commonly used...
5.
Mi S, Zhang J, Sun M, Huo X, Lv Y, Beier F, et al.
Exp Cell Res . 2023 Oct; 433(2):113824. PMID: 37890608
No abstract available.
6.
Hadzic E, To B, Pest M, Qin L, Beier F
Osteoarthr Cartil Open . 2023 Aug; 5(3):100387. PMID: 37547183
Background/objective: Osteoarthritis (OA) is a whole joint disorder with no disease modifying treatment currently available. The Epidermal Growth Factor Receptor (EGFR) signaling pathway plays an important role in cartilage/bone development...
7.
Chan B, Glogauer M, Wang Y, Wrana J, Chan K, Beier F, et al.
Sci Adv . 2023 Aug; 9(31):eadf1130. PMID: 37540756
In osteoarthritis (OA), a disease characterized by progressive articular cartilage degradation and calcification, the articular chondrocyte phenotype changes and this correlates with actin cytoskeleton alterations suggesting that it regulates gene...
8.
Strauss J, Deville J, Sznol M, Ravaud A, Maruzzo M, Pachynski R, et al.
J Immunother Cancer . 2023 May; 11(5). PMID: 37236636
Background: In preclinical studies, combining M9241 (a novel immunocytokine containing interleukin (IL)-12 heterodimers) with avelumab (anti-programmed death ligand 1 antibody) resulted in additive or synergistic antitumor effects. We report dose-escalation...
9.
Hadzic E, Beier F
Expert Opin Ther Targets . 2023 Feb; 27(2):111-120. PMID: 36851831
Introduction: Osteoarthritis is a heterogeneous joint disorder that lacks a clinically meaningful disease modifying drug. Animal models have been beneficial in understanding basic joint pathology and providing rationale for future...
10.
Sun M, Beier F
Osteoarthr Cartil Open . 2022 Dec; 2(1):100030. PMID: 36474558
Objective: Osteoarthritis (OA) is the most common type of arthritis and causes debilitating symptoms and decreased quality of life. A better understanding of the molecular mechanisms maintaining cartilage health is...