Alpha 2.0
Login Register
» Authors » T L Towers

T L Towers

Explore the profile of T L Towers including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 1502
Followers 0
Related Specialties
Cell Biology
Molecular Biology
Science
Co-Authors
L P Freedman
J V Ravetch
L G Presta
T P Staeva
A Asianov
R A Clynes
B F Luisi
A Samuelsson
I Alroy
Published In
Mol Cell Biol
Mol Endocrinol
J Biol Chem
Nat Med
Proc Natl Acad Sci U S A
Affiliations
Soon will be listed here.
Recent Articles
1.
Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor
Samuelsson A, Towers T, Ravetch J
Science . 2001 Feb; 291(5503):484-6. PMID: 11161202
The molecular basis for the anti-inflammatory property of intravenous gamma globulin (IVIG) was investigated in a murine model of immune thrombocytopenia. Administration of clinically protective doses of intact antibody or...
2.
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
Clynes R, Towers T, Presta L, Ravetch J
Nat Med . 2000 Mar; 6(4):443-6. PMID: 10742152
Inhibitory receptors have been proposed to modulate the in vivo cytotoxic response against tumor targets for both spontaneous and antibody-dependent pathways. Using a variety of syngenic and xenograft models, we...
3.
A two-hit mechanism for vitamin D3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene: vitamin D receptor competes for DNA binding with NFAT1 and stabilizes c-Jun
Towers T, Staeva T, Freedman L
Mol Cell Biol . 1999 May; 19(6):4191-9. PMID: 10330159
We previously described a control element in the granulocyte-macrophage colony-stimulating factor (GM-CSF) enhancer that is necessary and sufficient to mediate both transcriptional activation in response to T-cell stimuli and transcriptional...
4.
Granulocyte-macrophage colony-stimulating factor gene transcription is directly repressed by the vitamin D3 receptor. Implications for allosteric influences on nuclear receptor structure and function by a DNA element
Towers T, Freedman L
J Biol Chem . 1998 May; 273(17):10338-48. PMID: 9553089
The primary function of activated T lymphocytes is to produce various cytokines necessary to elicit an immune response; these cytokines include interleukin-2 (IL-2), interleukin-4, and granulocyte-macrophage colony-stimulating factor (GMCSF). Steroid...
5.
Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor
Alroy I, Towers T, Freedman L
Mol Cell Biol . 1995 Oct; 15(10):5789-99. PMID: 7565732
T-lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D3, and is associated with a decrease in interleukin 2 (IL-2), gamma interferon, and granulocyte-macrophage colony-stimulating factor...
6.
DNA target selectivity by the vitamin D3 receptor: mechanism of dimer binding to an asymmetric repeat element
Towers T, Luisi B, Asianov A, Freedman L
Proc Natl Acad Sci U S A . 1993 Jul; 90(13):6310-4. PMID: 8392196
The 1,25-dihydroxyvitamin D3 receptor, like other members of the nuclear receptor superfamily, forms dimers in solution that are probably stabilized by a dyad symmetrical interface formed by the ligand-binding domain....
7.
DNA binding properties of the vitamin D3 receptor zinc finger region
Freedman L, Towers T
Mol Endocrinol . 1991 Dec; 5(12):1815-26. PMID: 1665202
The DNA binding domains of the nuclear receptor superfamily are highly conserved and consist of residues that fold into two zinc finger-like motifs, suggesting that the structures of this region...