L G Presta
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Explore the profile of L G Presta including associated specialties, affiliations and a list of published articles.
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48
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3856
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Recent Articles
1.
Presta L, Shields R, Namenuk A, Hong K, Meng Y
Biochem Soc Trans
. 2002 Aug;
30(4):487-90.
PMID: 12196120
The binding sites on human IgG1 for human Fc gamma receptor (Fc gamma R) I, Fc gamma RIIa, Fc gamma RIIb, Fc gamma RIIIa and neonatal FcR have been mapped....
2.
Gadek T, Burdick D, McDowell R, STANLEY M, Marsters Jr J, Paris K, et al.
Science
. 2002 Feb;
295(5557):1086-9.
PMID: 11834839
The protein-protein interaction between leukocyte functional antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) is critical to lymphocyte and immune system function. Here, we report on the transfer of the contiguous,...
3.
Chuntharapai A, Lai J, Huang X, Gibbs V, Kim K, Presta L, et al.
Cytokine
. 2001 Oct;
15(5):250-60.
PMID: 11594789
We have developed a panel of murine monoclonal antibodies that recognize human interferon alpha. One of these mononclonal antibodies binds and neutralizes, with high affinity, all of seven tested recombinant...
4.
Idusogie E, Wong P, Presta L, Totpal K, Ultsch M, Mulkerrin M
J Immunol
. 2001 Feb;
166(4):2571-5.
PMID: 11160318
This manuscript describes two sites in a human IgG1 that, when mutated individually or in combination, result in a dramatic increase in C1q binding and complement-dependent cytotoxicity activity. These two...
5.
Idusogie E, Presta L, Totpal K, Wong P, Ultsch M, Meng Y, et al.
J Immunol
. 2001 Feb;
164(8):4178-84.
PMID: 10754313
Rituxan (Rituximab) is a chimeric mAb with human IgG1 constant domains used in the therapy of non-Hodgkin's B cell lymphomas. This Ab targets B cells by binding to the cell-surface...
6.
Shields R, Namenuk A, Hong K, Meng Y, RAE J, Briggs J, et al.
J Biol Chem
. 2000 Nov;
276(9):6591-604.
PMID: 11096108
Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1...
7.
Clynes R, Towers T, Presta L, Ravetch J
Nat Med
. 2000 Mar;
6(4):443-6.
PMID: 10742152
Inhibitory receptors have been proposed to modulate the in vivo cytotoxic response against tumor targets for both spontaneous and antibody-dependent pathways. Using a variety of syngenic and xenograft models, we...
8.
OConnell L, Hongo J, Presta L, Tsoulfas P
J Biol Chem
. 2000 Mar;
275(11):7870-7.
PMID: 10713102
Neurotrophins are important for the development and maintenance of the vertebrate nervous system, mediating their signal into the cell by specific interaction with tyrosine kinase receptors of the Trk family....
9.
Edwards C, Fisher K, Presta L, Bodary S
J Biol Chem
. 1998 Oct;
273(44):28937-44.
PMID: 9786897
By extensive mutagenic analysis of the inserted domain (I-domain) of the alpha-chain (CD11a) of the leukocyte function-associated antigen-1 (LFA-1), we have defined a putative binding surface for intercellular adhesion molecules...
10.
OConnor S, Meng Y, Rezaie A, Presta L
Protein Eng
. 1998 Jul;
11(4):321-8.
PMID: 9680194
A murine monoclonal antibody to the zymogen form of human protein C that blocks protein C activation by thrombin-thrombomodulin both in vitro and in vivo has been humanized using the...