T L MURPHY
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Explore the profile of T L MURPHY including associated specialties, affiliations and a list of published articles.
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53
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1825
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Recent Articles
11.
Farrar J, Smith J, MURPHY T, Leung S, Stark G, Murphy K
Nat Immunol
. 2001 Mar;
1(1):65-9.
PMID: 10881177
The use of murine systems to model pathogen-induced human diseases presumes that general immune mechanisms between these species are conserved. One important immunoregulatory mechanism involves linkage of innate and adaptive...
12.
Murphy K, Ouyang W, Ranganath S, MURPHY T
Cold Spring Harb Symp Quant Biol
. 2001 Mar;
64:585-8.
PMID: 11232335
No abstract available.
13.
MURPHY T, Geissal E, Farrar J, Murphy K
Mol Cell Biol
. 2000 Sep;
20(19):7121-31.
PMID: 10982828
Stat4 is activated by the cytokines interleukin 12 and alpha interferon (IFN-alpha) and plays a significant role in directing development of naïve CD4(+) T cells to the Th1 phenotype. Signal...
14.
Murphy K, Ouyang W, Farrar J, Yang J, Ranganath S, Asnagli H, et al.
Annu Rev Immunol
. 2000 Jun;
18:451-94.
PMID: 10837066
The recognition of polarized T cell subsets defined by cytokine production was followed by a search to define the factors controlling this phenomenon. Suitable in vitro systems allowed the development...
15.
Farrar J, Smith J, MURPHY T, Murphy K
J Biol Chem
. 2000 Jan;
275(4):2693-7.
PMID: 10644731
Stat4 activation is involved in differentiation of type 1 helper (Th1) T cells. Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells, Stat4 is activated...
16.
Ouyang W, Jacobson N, Bhattacharya D, Gorham J, Fenoglio D, Sha W, et al.
Proc Natl Acad Sci U S A
. 1999 Mar;
96(7):3888-93.
PMID: 10097133
Interleukin 12 (IL-12)-induced T helper 1 (Th1) development requires Stat4 activation. However, antigen-activated Th1 cells can produce interferon gamma (IFN-gamma) independently of IL-12 and Stat4 activation. Thus, in differentiated Th1...
17.
Murphy K, Ouyang W, Szabo S, Jacobson N, Guler M, Gorham J, et al.
Curr Top Microbiol Immunol
. 1999 Mar;
238:13-26.
PMID: 10087648
Much of our focus in understanding Th1/Th2 development has been on the signals delivered by IL-12 and IL-4 as final determinants of terminal T cell differentiation. Because extinction of IL-12...
18.
Yang J, MURPHY T, Ouyang W, Murphy K
Eur J Immunol
. 1999 Mar;
29(2):548-55.
PMID: 10064070
IFN-gamma produced by CD4+ T helper 1 (Th1) cells promotes protection against intracellular pathogens. Antigen activation of Th1 cells is an important mode of IFN-gamma induction, but here we analyze...
19.
Vulpe C, Kuo Y, MURPHY T, Cowley L, Askwith C, Libina N, et al.
Nat Genet
. 1999 Feb;
21(2):195-9.
PMID: 9988272
Iron is essential for many cellular functions; consequently, disturbances of iron homeostasis, leading to either iron deficiency or iron overload, can have significant clinical consequences. Despite the clinical prevalence of...
20.
Guler M, Gorham J, Dietrich W, MURPHY T, Steen R, Parvin C, et al.
J Immunol
. 1999 Feb;
162(3):1339-47.
PMID: 9973388
Th phenotype development is controlled not only by cytokines but also by other parameters including genetic background. One site of genetic variation between murine strains that has direct impact on...