T Crabbe
Overview
Explore the profile of T Crabbe including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
30
Citations
623
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Perry M, OConnell J, Walker C, Crabbe T, Baldock D, Russell A, et al.
Cell Biochem Biophys
. 1998 Jun;
29(1-2):113-32.
PMID: 9631241
We present the in vitro characterization of a novel phosphodiesterase type 4 inhibitor, CDP840 (R-[+]-4-[2-¿3-cyclopentyloxy-4-methoxyphenyl¿-2-phenylethyl]pyridine), which has shown efficacy in a phase II allergen challenge study in asthmatics without adverse...
12.
Cockett M, Murphy G, Birch M, OConnell J, Crabbe T, Millican A, et al.
Biochem Soc Symp
. 1998 Mar;
63:295-313.
PMID: 9513731
The rationale for matrix metalloproteinase (MMP) inhibition as a means to treat disease progression in breast cancer stems from the apparent involvement of MMPs in the hydrolysis of basement membranes...
13.
Butler G, Butler M, Atkinson S, Will H, Tamura T, Schade van Westrum S, et al.
J Biol Chem
. 1998 Feb;
273(2):871-80.
PMID: 9422744
We have used C-terminal domain mutants to further define the role of interactions of progelatinase A and membrane type 1 matrix metalloproteinase (MT1 MMP) in the binding of TIMP2 and...
14.
Owens R, Lumb S, Rees-Milton K, Russell A, Baldock D, Lang V, et al.
Cell Signal
. 1998 Jan;
9(8):575-85.
PMID: 9429761
A cDNA coding for a human phosphodiesterase 4C (PDE4C2) was isolated from the mRNA prepared from the glioblastoma cell line, U87. The cDNA contained an ORF of 1818 bp corresponding...
15.
Crabbe T, Donmall M
Addiction
. 1996 Oct;
91(10):1547-50.
PMID: 8917922
This paper describes the anonymous, attributable code which is applied to different individuals when they are reported to the regional drug misuse databases using the University of Manchester system. It...
16.
Crabbe T, Weir A, Walton E, Brown M, Sutton C, Tretout N, et al.
Protein Expr Purif
. 1996 May;
7(3):229-36.
PMID: 8860647
The expression of the complete human gastric lipase (HGL) gene in Saceharomyces cerevisiae grown in defined medium resulted in the secretion of active recombinant HGL (rec.HGL) to levels of up...
17.
Crabbe T, Kelly S, Price N
FEBS Lett
. 1996 Feb;
380(1-2):53-7.
PMID: 8603746
The latent precursors of the matrix metalloproteinases (MMPs) are converted by (4-aminophenylmercuric)acetate to active forms that lose their propeptide as a result of autolysis. C.D. and an active site mutant...
18.
Gohlke U, Gomis-Ruth F, Crabbe T, Murphy G, Docherty A, Bode W
FEBS Lett
. 1996 Jan;
378(2):126-30.
PMID: 8549817
In common with most other matrix metalloproteinases, gelatinase A has a non-catalytic C-terminal domain that displays sequence homology to haemopexin. Crystals of this domain were used by molecular replacement to...
19.
Atkinson S, Crabbe T, Cowell S, WARD R, Butler M, Sato H, et al.
J Biol Chem
. 1995 Dec;
270(51):30479-85.
PMID: 8530478
Membrane-type matrix metalloproteinase (MT-MMP) messenger RNA and protein expression were shown to be elevated in human fibroblasts following treatment with concanavalin A, coincident with the induction of the ability to...
20.
Chander S, Antoniw P, Beeley N, Boyce B, Crabbe T, Docherty A, et al.
J Pharm Sci
. 1995 Apr;
84(4):404-9.
PMID: 7629728
Gelatinase A, a matrix metalloproteinase, is frequently associated with human solid tumors, and its secretion and activation in the tumor milieu is considered important in the process of angiogenesis, invasion,...