T C Dickson
Overview
Explore the profile of T C Dickson including associated specialties, affiliations and a list of published articles.
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22
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485
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Recent Articles
1.
Clark J, Chuckowree J, Dyer M, Dickson T, Blizzard C
Sci Rep
. 2020 Jan;
10(1):918.
PMID: 31969604
Brain penetrant microtubule stabilising agents (MSAs) are being increasingly validated as potential therapeutic strategies for neurodegenerative diseases and traumatic injuries of the nervous system. MSAs are historically used to treat...
2.
Clark J, Blizzard C, Breslin M, Yeaman E, Lee K, Chuckowree J, et al.
Neuropathol Appl Neurobiol
. 2018 Jan;
44(6):590-605.
PMID: 29380402
Aims: Degeneration of the distal neuromuscular circuitry is a hallmark pathology of Amyotrophic Lateral Sclerosis (ALS). The potential for microtubule dysfunction to be a critical pathophysiological mechanism in the destruction...
3.
Musgrove R, King A, Dickson T
Neurotox Res
. 2010 Jul;
19(4):592-602.
PMID: 20617407
α-Synuclein is the major protein component of Lewy bodies--the pathological hallmark of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). Its accumulation into intracellular aggregates is implicated in the...
4.
Pountney D, Dickson T, Power J, Vickers J, West A, Gai W
Neurotox Res
. 2009 Dec;
19(1):115-22.
PMID: 20039155
Multiple system atrophy (MSA) is an adult-onset neurodegenerative disease characterised by Parkinsonian and autonomic symptoms and by widespread intracytoplasmic inclusion bodies in oligodendrocytes. These glial cytoplasmic inclusions (GCIs) are comprised...
5.
King A, Dickson T, Blizzard C, Woodhouse A, Foster S, Chung R, et al.
Neurobiol Aging
. 2009 May;
32(3):459-69.
PMID: 19427060
Amyotrophic lateral sclerosis (ALS) is a devastating disorder involving loss of movement due to degeneration of motor neurons. Studies suggest that in ALS axonal dysfunction precedes the death of motor...
6.
King A, Dickson T, Blizzard C, Foster S, Chung R, West A, et al.
Eur J Neurosci
. 2007 Oct;
26(8):2151-9.
PMID: 17908171
Excitotoxicity has been implicated as a potential cause of neuronal degeneration in amyotrophic lateral sclerosis (ALS). It has not been clear how excitotoxic injury leads to the hallmark pathological changes...
7.
Blizzard C, Haas M, Vickers J, Dickson T
Eur J Neurosci
. 2007 Sep;
26(5):1100-8.
PMID: 17767489
While long-distance regeneration may be limited in mammalian species, it is becoming apparent that damaged mature neurons retain some capacity for attempted regeneration and that the adult CNS is not...
8.
Staal J, Dickson T, Chung R, Vickers J
Dev Neurobiol
. 2007 Aug;
67(14):1831-42.
PMID: 17702000
Following central nervous system trauma, diffuse axonal injury and secondary axotomy result from a cascade of cellular alterations including cytoskeletal and mitochondrial disruption. We have examined the link between intracellular...
9.
King A, Chung R, Vickers J, Dickson T
J Comp Neurol
. 2006 Jul;
498(2):277-94.
PMID: 16856139
Overactivation of glutamate receptors leading to excitotoxicity has been implicated in the neurodegenerative alterations of a range of central nervous system (CNS) disorders. We have investigated the cell-type-specific changes in...
10.
Quilty M, King A, Gai W, Pountney D, West A, Vickers J, et al.
Exp Neurol
. 2005 Nov;
199(2):249-56.
PMID: 16310772
Chronic oxidative stress has been linked to the neurodegenerative changes characteristic of Parkinson's disease, particularly alpha-synuclein accumulation and aggregation. However, it remains contentious whether these alpha-synuclein changes are cytotoxic or...