Sytse J Piersma
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Explore the profile of Sytse J Piersma including associated specialties, affiliations and a list of published articles.
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32
Citations
1334
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Recent Articles
1.
Piersma S, Li S, Wong P, Bern M, Poursine-Laurent J, Yang L, et al.
Elife
. 2025 Mar;
13.
PMID: 40085489
Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like...
2.
Jo S, Ohara R, Theisen D, Kim S, Liu T, Bullock C, et al.
J Exp Med
. 2025 Feb;
222(4).
PMID: 39918736
Priming CD8+ T cells against tumors or viral pathogens results largely from cross-presentation of exogenous antigens by type 1 conventional dendritic cells (cDC1s). Although monocyte-derived DCs and cDC2s can cross-present...
3.
Piersma S, Li S, Wong P, Bern M, Poursine-Laurent J, Yang L, et al.
bioRxiv
. 2024 Jun;
PMID: 38895234
Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like...
4.
Fan C, Xing X, Murphy S, Poursine-Laurent J, Schmidt H, Parikh B, et al.
Nat Commun
. 2024 Jun;
15(1):4839.
PMID: 38844462
Comparative genomics has revealed the rapid expansion of multiple gene families involved in immunity. Members within each gene family often evolved distinct roles in immunity. However, less is known about...
5.
Piersma S
Cell Mol Immunol
. 2024 Apr;
21(9):1036-1050.
PMID: 38684766
Innate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells and include...
6.
Piersma S, Bangru S, Yoon J, Liu T, Yang L, Hsieh C, et al.
J Exp Med
. 2023 Sep;
220(11).
PMID: 37698554
Natural killer (NK) cells are lymphocytes capable of controlling tumors and virus infections through direct lysis and cytokine production. While both T and NK cells expand and accumulate in affected...
7.
Li S, Bern M, Miao B, Fan C, Xing X, Inoue T, et al.
Elife
. 2022 Oct;
11.
PMID: 36190189
BTB domain And CNC Homolog 2 (Bach2) is a transcription repressor that actively participates in T and B lymphocyte development, but it is unknown if Bach2 is also involved in...
8.
Victorino F, Bigley T, Park E, Yao C, Benoit J, Yang L, et al.
Elife
. 2021 Aug;
10.
PMID: 34396954
Natural killer (NK) cells are essential for early protection against virus infection and must metabolically adapt to the energy demands of activation. Here, we found upregulation of the metabolic adaptor...
9.
Piersma S, Brizic I
FEBS J
. 2021 Jun;
289(14):3982-3999.
PMID: 34125493
Natural killer (NK) cells are innate lymphoid cells involved in the control of tumors and viral infections. They provide protection by producing cytokines and by directly lysing target cells. Both...
10.
Parikh B, Bern M, Piersma S, Yang L, Beckman D, Poursine-Laurent J, et al.
Cell Rep
. 2020 Jul;
32(4):107969.
PMID: 32726632
Major histocompatibility complex class I (MHC-I)-restricted immune responses are largely attributed to cytotoxic T lymphocytes (CTLs). However, natural killer (NK) cells, as predicted by the missing-self hypothesis, have opposing requirements...