Sylvie E Kandel
Overview
Explore the profile of Sylvie E Kandel including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
108
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0
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Recent Articles
1.
Kandel S, Tooker B, Lampe J
J Biol Chem
. 2024 Jul;
300(8):107594.
PMID: 39032655
Drug metabolism is one of the main processes governing the pharmacokinetics and toxicity of drugs via their chemical biotransformation and elimination. In humans, the liver, enriched with cytochrome P450 (CYP)...
2.
Work H, Kandel S, Lampe J
Drug Metab Dispos
. 2024 May;
52(11):1224-1233.
PMID: 38702193
The CYP3A7 enzyme accounts for ∼50% of the total cytochrome P450 (P450) content in fetal and neonatal livers and is the predominant P450 involved in neonatal xenobiotic metabolism. Additionally, it...
3.
Liu J, Kandel S, Lampe J, Scott E
J Biol Chem
. 2023 Oct;
299(10):105283.
PMID: 37783037
No abstract available.
4.
Kandel S, Gracey E, Lampe J
Chem Res Toxicol
. 2023 Sep;
36(10):1631-1642.
PMID: 37769118
Idiosyncratic drug reactions (IDRs) in their most deleterious form can lead to serious medical complications and potentially fatal events. Nevirapine (NVP), still widely used in developing countries for combinatorial antiretroviral...
5.
Liu J, Kandel S, Lampe J, Scott E
J Biol Chem
. 2023 Jul;
299(8):104993.
PMID: 37392852
Human fetal cytochrome P450 3A7 (CYP3A7) is involved in both xenobiotic metabolism and the estriol biosynthetic pathway. Although much is understood about cytochrome P450 3A4 and its role in adult...
6.
Hvizdak M, Kandel S, Work H, Gracey E, McCullough R, Lampe J
J Inorg Biochem
. 2023 Jan;
240:112120.
PMID: 36638633
Per- and polyfluoroalkyl substances (PFAS) are a chemical class of highly stable, fluorinated compounds popular for use in a variety of consumer products. PFAS environmental persistence in drinking water contributes...
7.
Hicks E, Kandel S, Lampe J
Bioorg Med Chem Lett
. 2022 Apr;
66:128732.
PMID: 35427739
In the past two years, the COVID-19 pandemic has caused over 5 million deaths and 250 million infections worldwide. Despite successful vaccination efforts and emergency approval of small molecule therapies,...
8.
Tooker B, Kandel S, Work H, Lampe J
J Biol Chem
. 2022 Jan;
298(3):101629.
PMID: 35085556
Pseudomonas aeruginosa is a Gram-negative opportunistic human pathogen that is highly prevalent in individuals with cystic fibrosis (CF). A major problem in treating CF patients infected with P. aeruginosa is...
9.
Work H, Kandel S, Lampe J
Sci Rep
. 2021 Oct;
11(1):19443.
PMID: 34593846
CYP3A7 is a member of the cytochrome P450 (CYP) 3A enzyme sub-family that is expressed in the fetus and neonate. In addition to its role metabolizing retinoic acid and the...
10.
Kandel S, Lampe J
Chem Res Toxicol
. 2021 Apr;
34(4):1150-1160.
PMID: 33821626
Prophylactic antiretroviral therapy (ART) in HIV infected pregnant mothers and their newborns can dramatically reduce mother-to-child viral transmission and seroconversion in the neonate. The ritonavir-boosted lopinavir regimen, known as Kaletra,...