Sylvain J Le Marchand
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Explore the profile of Sylvain J Le Marchand including associated specialties, affiliations and a list of published articles.
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12
Citations
759
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Recent Articles
1.
Shihan M, Novo S, Le Marchand S, Wang Y, Duncan M
Biochem Biophys Rep
. 2021 Feb;
25:100916.
PMID: 33553685
Western blotting (WB), enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FC) have long been used to assess and quantitate relative protein expression in cultured cells and tissue samples. However, WB...
2.
Henderson N, Le Marchand S, Hruska M, Hippenmeyer S, Luo L, Dalva M
Elife
. 2019 Feb;
8.
PMID: 30789343
Cortical networks are characterized by sparse connectivity, with synapses found at only a subset of axo-dendritic contacts. Yet within these networks, neurons can exhibit high connection probabilities, suggesting that cell-intrinsic...
3.
Ellens H, Meng Z, Le Marchand S, Bentz J
Expert Opin Drug Metab Toxicol
. 2018 May;
14(6):571-584.
PMID: 29788828
In vitro transporter kinetics are typically analyzed by steady-state Michaelis-Menten approximations. However, no clear evidence exists that these approximations, applied to multiple transporters in biological membranes, yield system-independent mechanistic parameters...
4.
Hruska M, Henderson N, Le Marchand S, Jafri H, Dalva M
Nat Neurosci
. 2018 Apr;
21(5):671-682.
PMID: 29686261
Experience results in long-lasting changes in dendritic spine size, yet how the molecular architecture of the synapse responds to plasticity remains poorly understood. Here a combined approach of multicolor stimulated...
5.
Zhao X, Sehgal M, Hou Z, Cheng J, Shu S, Wu S, et al.
J Virol
. 2017 Dec;
92(6).
PMID: 29263263
Interferon-induced transmembrane proteins (IFITMs) are restriction factors that inhibit the infectious entry of many enveloped RNA viruses. However, we demonstrated previously that human IFITM2 and IFITM3 are essential host factors...
6.
Hruska M, Henderson N, Xia N, Le Marchand S, Dalva M
Nat Neurosci
. 2015 Oct;
18(11):1594-605.
PMID: 26479588
Organization of signaling complexes at excitatory synapses by membrane-associated guanylate kinase (MAGUK) proteins regulates synapse development, plasticity, senescence and disease. Post-translational modification of MAGUK family proteins can drive their membrane...
7.
Benninger R, Hutchens T, Head W, McCaughey M, Zhang M, Le Marchand S, et al.
Biophys J
. 2014 Dec;
107(11):2723-33.
PMID: 25468351
Insulin is released from the islets of Langerhans in discrete pulses that are linked to synchronized oscillations of intracellular free calcium ([Ca(2+)]i). Associated with each synchronized oscillation is a propagating...
8.
Jepson J, Shahidullah M, Liu D, Le Marchand S, Liu S, Wu M, et al.
Development
. 2014 Nov;
141(23):4548-57.
PMID: 25359729
Synaptic scaffold proteins control the localization of ion channels and receptors, and facilitate molecular associations between signaling components that modulate synaptic transmission and plasticity. Here, we define novel roles for...
9.
Shahidullah M, Le Marchand S, Fei H, Zhang J, Pandey U, Dalva M, et al.
J Neurosci
. 2013 Dec;
33(50):19590-8.
PMID: 24336723
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease that leads invariably to fatal paralysis associated with motor neuron degeneration and muscular atrophy. One gene associated with ALS encodes the...
10.
Le Marchand S, Piston D
PLoS One
. 2012 Oct;
7(10):e47084.
PMID: 23077547
The mechanisms of glucagon secretion and its suppression by glucose are presently unknown. This study investigates the relationship between intracellular calcium levels ([Ca(2+)](i)) and hormone secretion under low and high...