Vikram Khurana
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Explore the profile of Vikram Khurana including associated specialties, affiliations and a list of published articles.
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2557
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Recent Articles
1.
Kadowaki A, Wheeler M, Li Z, Andersen B, Lee H, Illouz T, et al.
Nat Neurosci
. 2025 Mar;
28(3):470-486.
PMID: 40033124
Astrocytes promote neuroinflammation and neurodegeneration in multiple sclerosis (MS) through cell-intrinsic activities and their ability to recruit and activate other cell types. In a genome-wide CRISPR-based forward genetic screen investigating...
2.
Mesentier-Louro L, Goldman C, Ndayisaba A, Buonfiglioli A, Rooklin R, Schuldt B, et al.
bioRxiv
. 2025 Feb;
PMID: 39975381
The pathological hallmark of neurodegenerative disease is the aberrant post-translational modification and aggregation of proteins leading to the formation of insoluble protein inclusions. Genetic factors like are known to increase...
3.
Nunes A, Patel S, Oubre B, Jas M, Kulkarni D, Luddy A, et al.
medRxiv
. 2025 Feb;
PMID: 39974013
Quantitative analysis of human behavior is critical for objective characterization of neurological phenotypes, early detection of neurodegenerative diseases, and development of more sensitive measures of disease progression to support clinical...
4.
Lam I, Ndayisaba A, Lewis A, Fu Y, Sagredo G, Kuzkina A, et al.
Neuron
. 2025 Feb;
113(4):637.
PMID: 39894019
No abstract available.
5.
Nazeen S, Wang X, Morrow A, Strom R, Ethier E, Ritter D, et al.
bioRxiv
. 2025 Jan;
PMID: 39829934
Gene networks encapsulate biological knowledge, often linked to polygenic diseases. While model system experiments generate many plausible gene networks, validating their role in human phenotypes requires evidence from human genetics....
6.
Ndayisaba A, Halliday G, Khurana V
Annu Rev Pathol
. 2024 Oct;
20(1):245-273.
PMID: 39405585
Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by autonomic failure and motor impairment. The hallmark pathologic finding in MSA is widespread oligodendroglial cytoplasmic inclusions rich in aggregated...
7.
Maltby C, Krans A, Grudzien S, Palacios Y, Muinos J, Suarez A, et al.
Sci Adv
. 2024 Sep;
10(36):eadn2321.
PMID: 39231235
Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a recessively inherited neurodegenerative disorder caused by intronic biallelic, nonreference CCCTT/AAGGG repeat expansions within . To investigate how these repeats...
8.
Lam I, Ndayisaba A, Lewis A, Fu Y, Sagredo G, Kuzkina A, et al.
Neuron
. 2024 Jul;
112(17):2886-2909.e16.
PMID: 39079530
The heterogeneity of protein-rich inclusions and its significance in neurodegeneration is poorly understood. Standard patient-derived iPSC models develop inclusions neither reproducibly nor in a reasonable time frame. Here, we developed...
9.
Chia R, Ray A, Shah Z, Ding J, Ruffo P, Fujita M, et al.
Neuron
. 2024 May;
112(13):2142-2156.e5.
PMID: 38701790
Multiple system atrophy (MSA) is an adult-onset, sporadic synucleinopathy characterized by parkinsonism, cerebellar ataxia, and dysautonomia. The genetic architecture of MSA is poorly understood, and treatments are limited to supportive...
10.
Nazeen S, Wang X, Zielinski D, Lam I, Hallacli E, Xu P, et al.
bioRxiv
. 2024 Mar;
PMID: 38496508
Whether neurodegenerative diseases linked to misfolding of the same protein share genetic risk drivers or whether different protein-aggregation pathologies in neurodegeneration are mechanistically related remains uncertain. Conventional genetic analyses are...