Susamma Abraham
Overview
Explore the profile of Susamma Abraham including associated specialties, affiliations and a list of published articles.
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28
Citations
949
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Recent Articles
1.
Orsini E, Roychowdhury S, Gangadhariah M, Cross E, Abraham S, Reinhardt A, et al.
Am J Respir Cell Mol Biol
. 2024 Feb;
70(6):457-467.
PMID: 38346220
Sepsis is a systemic inflammatory response that requires effective macrophage metabolic functions to resolve ongoing inflammation. Previous work showed that the mechanosensitive cation channel, transient receptor potential vanilloid 4 (TRPV4),...
2.
A novel mechanoeffector role of fibroblast S100A4 in myofibroblast transdifferentiation and fibrosis
Southern B, Li H, Mao H, Crish J, Grove L, Scheraga R, et al.
J Biol Chem
. 2023 Dec;
300(1):105530.
PMID: 38072048
Fibroblast to myofibroblast transdifferentiation mediates numerous fibrotic disorders, such as idiopathic pulmonary fibrosis (IPF). We have previously demonstrated that non-muscle myosin II (NMII) is activated in response to fibrotic lung...
3.
Torbic H, Chen A, Lumpkin M, Yerke J, Mehkri O, Abraham S, et al.
J Intensive Care Med
. 2023 Sep;
39(4):313-319.
PMID: 37724016
We sought to evaluate critically ill patients with delirium to evaluate inflammatory cytokine production and delirium progression and the role of antipsychotics. Adult critically ill patients with confirmed delirium according...
4.
Gandhirajan A, Roychowdhury S, Kibler C, Cross E, Abraham S, Bellar A, et al.
Front Immunol
. 2023 Mar;
13:1079962.
PMID: 36865524
Alcohol abuse, reported by 1/8 critically ill patients, is an independent risk factor for death in sepsis. Sepsis kills over 270,000 patients/year in the US. We reported that the ethanol-exposure...
5.
Scheraga R, Abraham S, Grove L, Southern B, Crish J, Perelas A, et al.
J Immunol
. 2020 Jan;
204(5):1310-1321.
PMID: 31969384
Mechanical cell-matrix interactions can drive the innate immune responses to infection; however, the molecular underpinnings of these responses remain elusive. This study was undertaken to understand the molecular mechanism by...
6.
Grove L, Mohan M, Abraham S, Scheraga R, Southern B, Crish J, et al.
Sci Signal
. 2019 Nov;
12(607).
PMID: 31719171
Myofibroblasts are key contributors to pathological fibrotic conditions of several major organs. The transdifferentiation of fibroblasts into myofibroblasts requires both a mechanical signal and transforming growth factor-β (TGF-β) signaling. The...
7.
Yerke J, Sacha G, Scheraga R, Culver D, Abraham S, Torbic H, et al.
Pharmacotherapy
. 2019 Nov;
40(1):33-39.
PMID: 31705703
Introduction: Positive hemodynamic response to vasopressin after 6 hours of infusion was independently associated with lower mortality in a previous retrospective study of patients with septic shock. However, factors previously ...
8.
Southern B, Grove L, Rahaman S, Abraham S, Scheraga R, Niese K, et al.
J Biol Chem
. 2016 Jan;
291(12):6083-95.
PMID: 26763235
Pro-fibrotic mesenchymal cells are known to be the key effector cells of fibroproliferative disease, but the specific matrix signals and the induced cellular responses that drive the fibrogenic phenotype remain...
9.
Scheraga R, Abraham S, Niese K, Southern B, Grove L, Hite R, et al.
J Immunol
. 2015 Nov;
196(1):428-36.
PMID: 26597012
Macrophage phagocytosis of particles and pathogens is an essential aspect of innate host defense. Phagocytic function requires cytoskeletal rearrangements that depend on the interaction between macrophage surface receptors, particulates/pathogens, and...
10.
Rahaman S, Grove L, Paruchuri S, Southern B, Abraham S, Niese K, et al.
J Clin Invest
. 2014 Nov;
124(12):5225-38.
PMID: 25365224
Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disorder with no effective medical treatments available. The generation of myofibroblasts, which are critical for fibrogenesis, requires both a mechanical signal...