Sumeet Pal Singh
Overview
Explore the profile of Sumeet Pal Singh including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
619
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Recent Articles
1.
Akhtar M, Hnatiuk A, Delgadillo-Silva L, Geravandi S, Sameith K, Reinhardt S, et al.
EMBO J
. 2025 Jan;
44(4):1131-1153.
PMID: 39762647
While pancreatic beta-cell proliferation has been extensively studied, the role of cell death during islet development remains incompletely understood. Using a genetic model of caspase inhibition in beta cells coupled...
2.
Suner I, Singh S
Methods Mol Biol
. 2024 Nov;
2871:145-153.
PMID: 39565585
Proteins are the major and most diverse biomolecules, directing all activities of a cell. For this reason, visualizing protein expression, localization, and dynamics is fundamental in biology. In most cases,...
3.
Gilglioni E, Li A, St-Pierre-Wijckmans W, Shen T, Perez-Chavez I, Hovhannisyan G, et al.
Nat Commun
. 2024 Nov;
15(1):9522.
PMID: 39496584
Fat accumulation, de novo lipogenesis, and glycolysis are key drivers of hepatocyte reprogramming and the consequent metabolic dysfunction-associated steatotic liver disease (MASLD). Here we report that obesity leads to dysregulated...
4.
Pozo-Morales M, Singh S
Methods Mol Biol
. 2024 Oct;
2861:275-283.
PMID: 39395112
Calcium imaging has emerged as a powerful tool for studying cellular dynamics, with applications spanning neuroscience, cell biology, and beyond. In this chapter, we present a comprehensive guide to the...
5.
Delgadillo-Silva L, Tasoz E, Singh S, Chawla P, Georgiadou E, Gompf A, et al.
Sci Adv
. 2024 Jun;
10(26):eado4513.
PMID: 38924394
Coordination of cellular activity through Ca enables β cells to secrete precise quantities of insulin. To explore how the Ca response is orchestrated in space and time, we implement optogenetic...
6.
Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
Pozo-Morales M, Cobham A, Centola C, McKinney M, Liu P, Perazzolo C, et al.
Life Sci Alliance
. 2024 Mar;
7(5).
PMID: 38467419
Starvation causes the accumulation of lipid droplets in the liver, a somewhat counterintuitive phenomenon that is nevertheless conserved from flies to humans. Much like fatty liver resulting from overfeeding, hepatic...
7.
Ibneeva L, Singh S, Sinha A, Eski S, Wehner R, Rupp L, et al.
PLoS Biol
. 2024 Feb;
22(2):e3002517.
PMID: 38422172
A subpopulation of deeply quiescent, so-called dormant hematopoietic stem cells (dHSCs) resides at the top of the hematopoietic hierarchy and serves as a reserve pool for HSCs. The state of...
8.
Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
Pozo-Morales M, Cobham A, Centola C, McKinney M, Liu P, Perazzolo C, et al.
bioRxiv
. 2024 Jan;
PMID: 38260657
Starvation causes the accumulation of lipid droplets in the liver, a somewhat counterintuitive phenomenon that is nevertheless conserved from flies to humans. Much like fatty liver resulting from overfeeding, hepatic...
9.
Vandenbempt V, Eski S, Brahma M, Li A, Negueruela J, Bruggeman Y, et al.
iScience
. 2024 Jan;
27(1):108694.
PMID: 38213620
An altered gut microbiota is associated with type 1 diabetes (T1D), affecting the production of short-chain fatty acids (SCFA) and glucose homeostasis. We previously demonstrated that enhancing serum acetate and...
10.
Yu Q, Walters H, Pasquini G, Singh S, Lachnit M, Oliveira C, et al.
Dev Cell
. 2023 Oct;
58(22):2416-2427.e7.
PMID: 37879337
Axolotl limb regeneration is accompanied by the transient induction of cellular senescence within the blastema, the structure that nucleates regeneration. The precise role of this blastemal senescent cell (bSC) population,...