Alexander A Szewczak
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Explore the profile of Alexander A Szewczak including associated specialties, affiliations and a list of published articles.
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25
Citations
307
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Recent Articles
1.
Methot J, Fischer C, Li C, Rivkin A, Ahearn S, Brown W, et al.
Bioorg Med Chem Lett
. 2015 Jul;
25(17):3495-500.
PMID: 26142947
The triazolyl amide γ-secretase modulators are potent alternatives to the cinnamyl amides that have entered the clinic for the treatment of Alzheimer's disease. Herein we build on the lead benzoazepinones...
2.
Methot J, Hoffman D, Witter D, Stanton M, Harrington P, Hamblett C, et al.
ACS Med Chem Lett
. 2014 Jun;
5(4):340-5.
PMID: 24900838
The identification and in vitro and in vivo characterization of a potent SHI-1:2 are described. Kinetic analysis indicated that biaryl inhibitors exhibit slow binding kinetics in isolated HDAC1 and HDAC2...
3.
Quintero C, Tran K, Szewczak A
J Lab Autom
. 2013 May;
18(4):296-305.
PMID: 23629143
One high-throughput technology gaining widespread adoption in industry and academia is acoustic liquid dispensing, in which focused sound waves eject nanoliter-sized droplets from a solution into a recipient microplate. This...
4.
Northrup A, Katcher M, Altman M, Chenard M, Daniels M, Deshmukh S, et al.
J Med Chem
. 2013 Feb;
56(6):2294-310.
PMID: 23379595
This report documents the first example of a specific inhibitor of protein kinases with preferential binding to the activated kinase conformation: 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one 11r (MK-8033), a dual c-Met/Ron inhibitor under investigation...
5.
Kraus M, Wang Y, Aleksandrowicz D, Bachman E, Szewczak A, Walker D, et al.
PLoS One
. 2012 May;
7(5):e37207.
PMID: 22623993
A high percentage of patients with the myeloproliferative disorder polycythemia vera (PV) harbor a Val617→Phe activating mutation in the Janus kinase 2 (JAK2) gene, and both cell culture and mouse...
6.
Fischer C, Zultanski S, Zhou H, Methot J, Shah S, Nuthall H, et al.
Bioorg Med Chem Lett
. 2012 Apr;
22(9):3140-6.
PMID: 22497762
Synthesis and SAR studies of novel aryl triazoles as gamma secretase modulators (GSMs) are presented in this communication. Starting from our aryl triazole leads, optimization studies were continued and the...
7.
Lim J, Taoka B, Otte R, Spencer K, Dinsmore C, Altman M, et al.
J Med Chem
. 2011 Sep;
54(20):7334-49.
PMID: 21942426
The JAK-STAT pathway mediates signaling by cytokines, which control survival, proliferation, and differentiation of a variety of cells. In recent years, a single point mutation (V617F) in the tyrosine kinase...
8.
Xu D, Ondeyka J, Harris G, Zink D, Nielsen Kahn J, Wang H, et al.
J Nat Prod
. 2011 Jul;
74(8):1721-30.
PMID: 21761939
In a whole-cell mechanism of action (MOA)-based screening strategy for discovery of antifungal agents, Candida albicans was used, followed by testing of active extracts in the C. albicans fitness test...
9.
Fischer C, Zultanski S, Zhou H, Methot J, Brown W, Mampreian D, et al.
Bioorg Med Chem Lett
. 2011 May;
21(13):4083-7.
PMID: 21616665
Synthesis, SAR, and evaluation of aryl triazoles as novel gamma secretase modulators (GSMs) are presented in this communication. Starting from the literature and in-house leads, we evaluated a range of...
10.
Katz J, Jewell J, Guerin D, Lim J, Dinsmore C, Deshmukh S, et al.
J Med Chem
. 2011 May;
54(12):4092-108.
PMID: 21608528
c-Met is a transmembrane tyrosine kinase that mediates activation of several signaling pathways implicated in aggressive cancer phenotypes. In recent years, research into this area has highlighted c-Met as an...