Sui-Po Zhang
Overview
Explore the profile of Sui-Po Zhang including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
335
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Recent Articles
1.
Zhu B, Connolly P, Zhang Y, McDonnell M, Bian H, Lin S, et al.
Bioorg Med Chem Lett
. 2020 Jun;
30(14):127243.
PMID: 32527545
Monoacylglycerol lipase (MAGL) is the enzyme that is primarily responsible for hydrolyzing the endocannabinoid 2-arachidononylglycerol (2-AG) to arachidonic acid (AA). It has emerged in recent years as a potential drug...
2.
Zhu B, Connolly P, Zhang S, Chevalier K, Milligan C, Flores C, et al.
Bioorg Med Chem Lett
. 2020 Apr;
30(12):127198.
PMID: 32334914
Monoacylglycerol lipase (MAGL) has emerged as an attractive drug target because of its important role in regulating the endocannabinoid 2-arachidonoylglycerol (2-AG) and its hydrolysis product arachidonic acid (AA) in the...
3.
Wyatt R, Fraser I, Welty N, Lord B, Wennerholm M, Sutton S, et al.
J Pharmacol Exp Ther
. 2019 Dec;
372(3):339-353.
PMID: 31818916
The serine hydrolase monoacylglycerol lipase (MAGL) is the rate-limiting enzyme responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) into arachidonic acid and glycerol. Inhibition of 2-AG degradation leads to...
4.
Douglass J, Zhou Y, Wu A, Zadroga J, Gajda A, Lackey A, et al.
J Lipid Res
. 2019 Mar;
60(3):717.
PMID: 30824679
No abstract available.
5.
Parsons W, Calvo R, Cheung W, Lee Y, Patel S, Liu J, et al.
J Med Chem
. 2015 Apr;
58(9):3859-74.
PMID: 25850459
Reported herein is the design, synthesis, and pharmacologic characterization of a class of TRPV1 antagonists constructed on a benzo[d]imidazole platform that evolved from a biaryl amide lead. This design composes...
6.
Douglass J, Zhou Y, Wu A, Zadroga J, Gajda A, Lackey A, et al.
J Lipid Res
. 2015 Apr;
56(6):1153-71.
PMID: 25842377
Monoacylglycerol lipase (MGL) is a ubiquitously expressed enzyme that catalyzes the hydrolysis of monoacylglycerols (MGs) to yield FFAs and glycerol. MGL contributes to energy homeostasis through the mobilization of fat...
7.
Breslin H, Diamond C, Kavash R, Cai C, Dyatkin A, Miskowski T, et al.
Bioorg Med Chem Lett
. 2012 Jun;
22(14):4869-72.
PMID: 22695132
A small set of acyclic analogs 5 were prepared to explore their structure-activity relationships (SARs) relative to heterocyclic core, opioid receptor (OR) agonists 4. Compound 5l was found to have...
8.
Clemente J, Nulton E, Nelen M, Todd M, Maguire D, Schalk-Hihi C, et al.
J Biomol Screen
. 2012 Apr;
17(5):629-40.
PMID: 22496098
Endocannabinoids such as 2-arachidonylglycerol (2-AG) are ligands for cannabinoid receptors that contribute to the transmission and modulation of pain signals. The antinociceptive effect of exogenous 2-AG suggests that inhibition of...
9.
Codd E, Mabus J, Murray B, Zhang S, Flores C
Assay Drug Dev Technol
. 2011 Feb;
9(4):362-72.
PMID: 21323580
Classically, G protein-coupled receptor activation by a ligand has been viewed as producing a defined response such as activation of a G protein, activation or inhibition of adenylyl cyclase, or...
10.
Codd E, Baker J, Brandt M, Bryant S, Cai C, Carson J, et al.
Toxicol Sci
. 2010 Jul;
117(2):493-504.
PMID: 20616206
The unexpected observation of a hyperglycemic effect of some tricycle-based delta opioid receptor (DOR) agonists led to a series of studies to better understand the finding. Single administration of two...