Christopher M Flores
Overview
Explore the profile of Christopher M Flores including associated specialties, affiliations and a list of published articles.
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Articles
65
Citations
1827
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0
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Recent Articles
1.
Gelotte C, Vakil A, Zimmerman B, Zannikos P, Mishra R, Eichenbaum G, et al.
Regul Toxicol Pharmacol
. 2023 Aug;
:105480.
PMID: 37625518
JNJ-10450232 (NTM-006) is a non-opioid, non-NSAID analgesic and antipyretic compound with structural similarity to acetaminophen. Preclinical models show comparable analgesia relative to acetaminophen and no evidence of hepatotoxicity associated with...
2.
Lim H, Chen J, Lam W, Gong Y, Leclercq L, Silva J, et al.
Regul Toxicol Pharmacol
. 2023 Mar;
:105379.
PMID: 36931586
JNJ-10450232 (NTM-006), a novel non-opioid, non-nonsteroidal anti-inflammatory drug with structural similarities to acetaminophen, demonstrated anti-pyretic and/or analgesic activities in preclinical models and humans and reduced potential to cause hepatotoxicity in...
3.
Zhou J, Jonghe S, Codd E, Weiner S, Gallacher D, Stahle P, et al.
Regul Toxicol Pharmacol
. 2023 Jan;
:105334.
PMID: 36608923
JNJ-10450232 (NTM-006) is a new molecular entity that is structurally related to acetaminophen. A comprehensive non-clinical safety program was conducted to support first-in-human and clinical efficacy studies based on preclinical...
4.
Kern D, Teneralli R, Flores C, Wittenberg G, Gilbert J, Cepeda M
Psychiatr Res Clin Pract
. 2022 Sep;
4(1):12-20.
PMID: 36101715
Objective: To systematically identify novel pharmacological strategies for preventing or treating post-traumatic stress disorder (PTSD) by leveraging large-scale analysis of real-world observational data. Methods: Using a self-controlled study design, the...
5.
Gelotte C, Vakil A, Berwaerts J, Zimmerman B, Eichenbaum G, Flores C, et al.
Regul Toxicol Pharmacol
. 2022 Aug;
134:105236.
PMID: 35934140
JNJ-10450232 (NTM-006) is a new molecular entity that comprises structural similarities to acetaminophen and provides comparable analgesia in animals and humans without causing the hepatotoxicity associated with acetaminophen overdose in...
6.
Kern D, Cepeda M, Flores C, Wittenberg G
CNS Drugs
. 2021 Feb;
35(2):243-251.
PMID: 33537916
Background: Observational data may inform novel drug development programs by identifying previously unappreciated, clinical benefits of existing drugs. Several preclinical and clinical studies have suggested emergent therapeutic utility of drugs...
7.
Baptista-de-Souza D, Tavares-Ferreira D, Megat S, Sankaranarayanan I, Shiers S, Flores C, et al.
Neurobiol Pain
. 2020 Jun;
8:100049.
PMID: 32548337
Though sex differences in chronic pain have been consistently described in the literature, their underlying neural mechanisms are poorly understood. Previous work in humans has demonstrated that men and women...
8.
Zhu B, Connolly P, Zhang Y, McDonnell M, Bian H, Lin S, et al.
Bioorg Med Chem Lett
. 2020 Jun;
30(14):127243.
PMID: 32527545
Monoacylglycerol lipase (MAGL) is the enzyme that is primarily responsible for hydrolyzing the endocannabinoid 2-arachidononylglycerol (2-AG) to arachidonic acid (AA). It has emerged in recent years as a potential drug...
9.
Zhu B, Connolly P, Zhang S, Chevalier K, Milligan C, Flores C, et al.
Bioorg Med Chem Lett
. 2020 Apr;
30(12):127198.
PMID: 32334914
Monoacylglycerol lipase (MAGL) has emerged as an attractive drug target because of its important role in regulating the endocannabinoid 2-arachidonoylglycerol (2-AG) and its hydrolysis product arachidonic acid (AA) in the...
10.
Wyatt R, Fraser I, Welty N, Lord B, Wennerholm M, Sutton S, et al.
J Pharmacol Exp Ther
. 2019 Dec;
372(3):339-353.
PMID: 31818916
The serine hydrolase monoacylglycerol lipase (MAGL) is the rate-limiting enzyme responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) into arachidonic acid and glycerol. Inhibition of 2-AG degradation leads to...