Stuart McLaren
Overview
Explore the profile of Stuart McLaren including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
18832
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Recent Articles
1.
Nik-Zainal S, Davies H, Staaf J, Ramakrishna M, Glodzik D, Zou X, et al.
Nature
. 2019 Jan;
566(7742):E1.
PMID: 30659290
In the Methods section of this Article, 'greater than' should have been 'less than' in the sentence 'Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance...
2.
Wedge D, Gundem G, Mitchell T, Woodcock D, Martincorena I, Ghori M, et al.
Nat Genet
. 2018 Apr;
50(5):682-692.
PMID: 29662167
Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic...
3.
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik V, Paschka P, Roberts N, et al.
N Engl J Med
. 2016 Jun;
374(23):2209-2221.
PMID: 27276561
Background: Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the...
4.
Nik-Zainal S, Davies H, Staaf J, Ramakrishna M, Glodzik D, Zou X, et al.
Nature
. 2016 May;
534(7605):47-54.
PMID: 27135926
We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding...
5.
Yates L, Gerstung M, Knappskog S, Desmedt C, Gundem G, Van Loo P, et al.
Nat Med
. 2015 Jun;
21(7):751-9.
PMID: 26099045
The sequencing of cancer genomes may enable tailoring of therapeutics to the underlying biological abnormalities driving a particular patient's tumor. However, sequencing-based strategies rely heavily on representative sampling of tumors....
6.
Cooper C, Eeles R, Wedge D, Van Loo P, Gundem G, Alexandrov L, et al.
Nat Genet
. 2015 May;
47(6):689.
PMID: 26018901
No abstract available.
7.
Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P, McLaren S, et al.
Science
. 2015 May;
348(6237):880-6.
PMID: 25999502
How somatic mutations accumulate in normal cells is central to understanding cancer development but is poorly understood. We performed ultradeep sequencing of 74 cancer genes in small (0.8 to 4.7...
8.
Cooper C, Eeles R, Wedge D, Van Loo P, Gundem G, Alexandrov L, et al.
Nat Genet
. 2015 Mar;
47(4):367-372.
PMID: 25730763
Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were...
9.
Chew S, Lu D, Campos L, Scott K, Saci A, Wang J, et al.
Genome Biol
. 2014 Sep;
15(9):455.
PMID: 25260652
The in vivo validation of cancer mutations and genes identified in cancer genomics is resource-intensive because of the low throughput of animal experiments. We describe a mouse model that allows...
10.
Tubio J, Li Y, Ju Y, Martincorena I, Cooke S, Tojo M, et al.
Science
. 2014 Aug;
345(6196):1251343.
PMID: 25082706
Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are abundant in the human genome. L1 elements propagate through RNA intermediates. In the germ line, neighboring, nonrepetitive sequences...