Peter J Campbell
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Explore the profile of Peter J Campbell including associated specialties, affiliations and a list of published articles.
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270
Citations
54626
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Recent Articles
1.
Brzozowska N, Wu L, Khodzhaeva V, Griffiths W, Duckworth A, Jung H, et al.
Nat Genet
. 2025 Mar;
PMID: 40065168
Somatic variants accumulate in non-malignant tissues with age. Functional variants, leading to clonal advantage of hepatocytes, accumulate in the liver of patients with acquired chronic liver disease (CLD). Whether somatic...
2.
Kapadia C, Williams N, Dawson K, Watson C, Yousefzadeh M, Le D, et al.
Nature
. 2025 Mar;
PMID: 40044850
Haematopoietic stem cells maintain blood production throughout life. Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of the haematopoietic stem cell pool...
3.
Mahlke M, Lumerman L, Nath P, Chittenden C, Hoyt S, Koeppel J, et al.
bioRxiv
. 2025 Feb;
PMID: 39975122
Centromere location is specified by CENP-A, a centromere-specific histone that epigenetically propagates centromere identity. How CENP-A is epigenetically maintained at one location in rapidly evolving centromeric DNA is unknown. Using...
4.
Grobecker P, Berri S, Peden J, Chow K, Fielding C, Armogida I, et al.
BMC Med Genomics
. 2025 Jan;
18(1):24.
PMID: 39885506
Rearrangements involving the DUX4 gene (DUX4-r) define a subtype of paediatric and adult acute lymphoblastic leukaemia (ALL) with a favourable outcome. Currently, there is no 'standard of care' diagnostic method...
5.
Spencer Chapman M, Mitchell E, Yoshida K, Williams N, Fabre M, Ranzoni A, et al.
Nature
. 2025 Jan;
638(8051):729-738.
PMID: 39814886
DNA is subject to continual damage, leaving each cell with thousands of individual DNA lesions at any given moment. The efficiency of DNA repair means that most known classes of...
6.
Stratton M, Humphreys L, Alexandrov L, Balmain A, Brennan P, Campbell P, et al.
Cancer Discov
. 2025 Jan;
15(1):22-27.
PMID: 39801236
The Mutographs Cancer Grand Challenge team aimed to discover unknown causes of cancer through mutational epidemiology, an alliance of cancer epidemiology and somatic genomics. By generating whole-genome sequences from thousands...
7.
Santarsieri A, Mitchell E, Pham M, Sanghvi R, Jablonski J, Lee-Six H, et al.
Lancet Oncol
. 2024 Dec;
26(1):98-109.
PMID: 39674188
Background: Procarbazine-containing chemotherapy regimens are associated with cytopenias and infertility, suggesting stem-cell toxicity. When treating Hodgkin lymphoma, procarbazine in escalated-dose bleomycin-etoposide-doxorubicin-cyclophosphamide-vincristine-procarbazine-prednisolone (eBEACOPP) is increasingly replaced with dacarbazine (eBEACOPDac) to reduce...
8.
Spencer Chapman M, Wilk C, Boettcher S, Mitchell E, Dawson K, Williams N, et al.
Nature
. 2024 Oct;
635(8040):926-934.
PMID: 39478227
Allogeneic haematopoietic cell transplantation (HCT) replaces the stem cells responsible for blood production with those from a donor. Here, to quantify dynamics of long-term stem cell engraftment, we sequenced genomes...
9.
Williams M, Wang X, Bastos H, Grondys-Kotarba G, Wu Q, Jin S, et al.
Blood Adv
. 2024 Oct;
9(2):291-309.
PMID: 39374575
Adult hematopoietic stem cells (HSCs) are responsible for the lifelong production of blood and immune cells, a process regulated by extracellular cues, including cytokines. Many cytokines signal through the conserved...
10.
Kapadia C, Williams N, Dawson K, Watson C, Yousefzadeh M, Le D, et al.
bioRxiv
. 2024 Sep;
PMID: 39345649
Haematopoietic stem cells maintain blood production throughout life. While extensively characterised using the laboratory mouse, little is known about how the population is sustained and evolves with age. We isolated...