Andrew Menzies
Overview
Explore the profile of Andrew Menzies including associated specialties, affiliations and a list of published articles.
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51
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20456
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Recent Articles
1.
Ijaz J, Harry E, Raine K, Menzies A, Beal K, Quail M, et al.
Cell Genom
. 2024 Jan;
4(2):100484.
PMID: 38232733
The epigenetic landscape of cancer is regulated by many factors, but primarily it derives from the underlying genome sequence. Chromothripsis is a catastrophic localized genome shattering event that drives, and...
2.
Williams N, Lee J, Mitchell E, Moore L, Baxter E, Hewinson J, et al.
Nature
. 2022 Jan;
602(7895):162-168.
PMID: 35058638
Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the timing of driver mutations and subsequent clonal dynamics is limited. Here, using whole-genome sequencing of 1,013 clonal haematopoietic...
3.
Moore L, Cagan A, Coorens T, Neville M, Sanghvi R, Sanders M, et al.
Nature
. 2021 Aug;
597(7876):381-386.
PMID: 34433962
Over the course of an individual's lifetime, normal human cells accumulate mutations. Here we compare the mutational landscape in 29 cell types from the soma and germline using multiple samples...
4.
Lawson A, Abascal F, Coorens T, Hooks Y, ONeill L, Latimer C, et al.
Science
. 2020 Oct;
370(6512):75-82.
PMID: 33004514
The extent of somatic mutation and clonal selection in the human bladder remains unknown. We sequenced 2097 bladder microbiopsies from 20 individuals using targeted ( = 1914 microbiopsies), whole-exome (...
5.
Yoshida K, Gowers K, Lee-Six H, Chandrasekharan D, Coorens T, Maughan E, et al.
Nature
. 2020 Jan;
578(7794):266-272.
PMID: 31996850
Tobacco smoking causes lung cancer, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA. The profound effects of tobacco on...
6.
Wong-Pinto L, Menzies A, Ordonez J
Appl Microbiol Biotechnol
. 2020 Jan;
104(5):1859-1869.
PMID: 31925483
Mining is an important activity for many countries, especially some in development, such as Chile, where it is a pillar of its economy. However, it generates large impacts that are...
7.
Petljak M, Alexandrov L, Brammeld J, Price S, Wedge D, Grossmann S, et al.
Cell
. 2019 Mar;
176(6):1282-1294.e20.
PMID: 30849372
Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity...
8.
Nik-Zainal S, Davies H, Staaf J, Ramakrishna M, Glodzik D, Zou X, et al.
Nature
. 2019 Jan;
566(7742):E1.
PMID: 30659290
In the Methods section of this Article, 'greater than' should have been 'less than' in the sentence 'Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance...
9.
Wedge D, Gundem G, Mitchell T, Woodcock D, Martincorena I, Ghori M, et al.
Nat Genet
. 2018 Apr;
50(5):682-692.
PMID: 29662167
Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic...
10.
ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data
Raine K, Van Loo P, Wedge D, Jones D, Menzies A, Butler A, et al.
Curr Protoc Bioinformatics
. 2016 Dec;
56:15.9.1-15.9.17.
PMID: 27930809
We have developed ascatNgs to aid researchers in carrying out Allele-Specific Copy number Analysis of Tumours (ASCAT). ASCAT is capable of detecting DNA copy number changes affecting a tumor genome...