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Stuart H Yuspa

Explore the profile of Stuart H Yuspa including associated specialties, affiliations and a list of published articles. Areas
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Articles 88
Citations 2481
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Recent Articles
1.
Zhang H, Read A, Cataisson C, Yang H, Lee W, Turk B, et al.
Sci Signal . 2024 May; 17(836):eadd5073. PMID: 38743809
The Ras-mitogen-activated protein kinase (MAPK) pathway is a major target for cancer treatment. To better understand the genetic pathways that modulate cancer cell sensitivity to MAPK pathway inhibitors, we performed...
2.
Sanchez V, Craig-Lucas A, Cataisson C, Carofino B, Yuspa S
J Extracell Biol . 2024 Jan; 2(10). PMID: 38264628
Mouse models of breast cancer have revealed that tumor-bearing hosts must express the oxidoreductase CLIC4 to develop lung metastases. In the absence of host CLIC4, primary tumors grow but the...
3.
Ovejero D, Michel Z, Cataisson C, Saikali A, Galisteo R, Yuspa S, et al.
J Clin Invest . 2023 Mar; 133(9). PMID: 36943390
Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a mosaic RASopathy characterized by the association of dysplastic skeletal lesions, congenital skin nevi of epidermal and/or melanocytic origin, and FGF23-mediated hypophosphatemia. The primary...
4.
Cataisson C, Lee A, Zhang A, Mizes A, Korkmaz S, Carofino B, et al.
Carcinogenesis . 2022 Oct; 43(12):1149-1161. PMID: 36306264
Environmental and molecular carcinogenesis are linked by the discovery that chemical carcinogen induced-mutations in the Hras or Kras genes drives tumor development in mouse skin. Importantly, enhanced expression or allele...
5.
Al Khamici H, Sanchez V, Yan H, Cataisson C, Michalowski A, Yang H, et al.
J Biol Chem . 2022 Jul; 298(9):102275. PMID: 35863434
The chloride intracellular channel-4 (CLIC4) is one of the six highly conserved proteins in the CLIC family that share high structural homology with GST-omega in the GST superfamily. While CLIC4...
6.
Sanchez V, Yang H, Craig-Lucas A, Dubois W, Carofino B, Lack J, et al.
PLoS Genet . 2022 Jun; 18(6):e1010271. PMID: 35727842
The TGF-β-regulated Chloride Intracellular Channel 4 (CLIC4) is an essential participant in the formation of breast cancer stroma. Here, we used data available from the TCGA and METABRIC datasets to...
7.
Lee A, Fraser E, Flowers B, Kim J, Wong K, Cataisson C, et al.
Mol Carcinog . 2021 Sep; 60(12):799-812. PMID: 34534377
Cellular senescence is a well-documented response to oncogene activation in many tissues. Multiple pathways are invoked to achieve senescence indicating its importance to counteract the transforming activities of oncogenic stimulation....
8.
Lima-Junior D, Krishnamurthy S, Bouladoux N, Collins N, Han S, Chen E, et al.
Cell . 2021 Jun; 184(14):3794-3811.e19. PMID: 34166614
The microbiota plays a fundamental role in regulating host immunity. However, the processes involved in the initiation and regulation of immunity to the microbiota remain largely unknown. Here, we show...
9.
Bajpai D, Mehdizadeh S, Uchiyama A, Inoue Y, Sawaya A, Overmiller A, et al.
Oncogene . 2021 May; 40(21):3680-3694. PMID: 33947961
Cutaneous squamous cell carcinoma (cSCC) ranks second in the frequency of all skin cancers. The balance between keratinocyte proliferation and differentiation is disrupted in the pathological development of cSCC. DLX3...
10.
Carofino B, Dinshaw K, Ho P, Cataisson C, Michalowski A, Ryscavage A, et al.
Oncotarget . 2020 Jan; 10(68):7251-7275. PMID: 31921386
Chloride intracellular channel 4 (CLIC4) is a tumor suppressor implicated in processes including growth arrest, differentiation, and apoptosis. CLIC4 protein expression is diminished in the tumor parenchyma during progression in...