Stuart Bunting
Overview
Explore the profile of Stuart Bunting including associated specialties, affiliations and a list of published articles.
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40
Citations
1690
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Recent Articles
1.
Lopez M, Wendt D, Lawrence R, Gong K, Ong H, Yip B, et al.
PLoS One
. 2025 Jan;
20(1):e0315005.
PMID: 39752451
The GM2 gangliosidoses, Tay-Sachs disease and Sandhoff disease, are devastating neurodegenerative disorders caused by β-hexosaminidase A (HexA) deficiency. In the Sandhoff disease mouse model, rescue potential was severely reduced when...
2.
Handyside B, Zhang L, Yates B, Xie L, Ismail A, Murphy R, et al.
Hum Gene Ther
. 2023 Dec;
35(1-2):36-47.
PMID: 38126359
Adeno-associated virus (AAV) vectors are used to deliver therapeutic transgenes, but host immune responses may interfere with transduction and transgene expression. We evaluated prophylactic corticosteroid treatment on AAV5-mediated expression in...
3.
Handyside B, Ismail A, Zhang L, Yates B, Xie L, Sihn C, et al.
Mol Ther
. 2022 Nov;
30(12):3570-3586.
PMID: 36348622
Recombinant adeno-associated virus (rAAV) vectors are often produced in HEK293 or Spodoptera frugiperda (Sf)-based cell lines. We compared expression profiles of "oversized" (∼5,000 bp) and "standard-sized" (4,600 bp) rAAV5-human α1-antitrypsin...
4.
Magat J, Jones S, Baridon B, Agrawal V, Wong H, Giaramita A, et al.
J Biol Chem
. 2022 Oct;
298(12):102625.
PMID: 36306823
Mucopolysaccharidosis type IIIA (MPS IIIA) is a lysosomal storage disorder caused by N-sulfoglucosamine sulfohydrolase (SGSH) deficiency. SGSH removes the sulfate from N-sulfoglucosamine residues on the nonreducing end of heparan sulfate...
5.
Zhang L, Yates B, Murphy R, Liu S, Xie L, Handyside B, et al.
Mol Ther Methods Clin Dev
. 2022 Sep;
26:519-531.
PMID: 36092364
Valoctocogene roxaparvovec (AAV5-hFVIII-SQ) gene transfer provided reduced bleeding for adult clinical trial participants with severe hemophilia A. However, pediatric outcomes are unknown. Using a mouse model of hemophilia A, we...
6.
Liu S, Razon L, Ritchie O, Sihn C, Handyside B, Berguig G, et al.
Mol Ther Methods Clin Dev
. 2022 Jul;
26:61-71.
PMID: 35782594
Recombinant adeno-associated virus (AAV) is an effective platform for therapeutic gene transfer; however, tissue-tropism differences between species are a challenge for successful translation of preclinical results to humans. We evaluated...
7.
Fong S, Yates B, Sihn C, Mattis A, Mitchell N, Liu S, et al.
Nat Med
. 2022 Apr;
28(4):789-797.
PMID: 35411075
Factor VIII gene transfer with a single intravenous infusion of valoctocogene roxaparvovec (AAV5-hFVIII-SQ) has demonstrated clinical benefits lasting 5 years to date in people with severe hemophilia A. Molecular mechanisms...
8.
Sihn C, Handyside B, Liu S, Zhang L, Murphy R, Yates B, et al.
Mol Ther Methods Clin Dev
. 2022 Jan;
24:142-153.
PMID: 35036471
Valoctocogene roxaparvovec (AAV5-hFVIII-SQ) is an adeno-associated virus serotype 5 (AAV5)-based gene therapy vector containing a B-domain-deleted human coagulation factor VIII (hFVIII) gene controlled by a liver-selective promoter. AAV5-hFVIII-SQ is currently...
9.
Mundy C, Chung J, Koyama E, Bunting S, Mahimkar R, Pacifici M
J Orthop Res
. 2022 Jan;
40(10):2391-2401.
PMID: 34996123
Hereditary multiple exostoses (HME) is a rare, pediatric disorder characterized by osteochondromas that form along growth plates and provoke significant musculoskeletal problems. HME is caused by mutations in heparan sulfate...
10.
Wilson I, Vitelli C, Yu G, Pacheco G, Vincelette J, Bunting S, et al.
Toxicol Pathol
. 2021 Mar;
49(4):950-962.
PMID: 33691530
Scoring demyelination and regeneration in hematoxylin and eosin-stained nerves poses a challenge even for the trained pathologist. This article demonstrates how combinatorial multiplex immunohistochemistry (IHC) and quantitative digital pathology bring...