Steven T Gregory
Overview
Explore the profile of Steven T Gregory including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
686
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Recent Articles
1.
Aleksandrova E, Wu K, Tresco B, Syroegin E, Killeavy E, Balasanyants S, et al.
Nat Chem Biol
. 2024 Jan;
20(7):867-876.
PMID: 38238495
The bacterial ribosome is an essential drug target as many clinically important antibiotics bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is targeted by the broadest...
2.
Aleksandrova E, Wu K, Tresco B, Syroegin E, Killeavy E, Balasanyants S, et al.
bioRxiv
. 2023 Oct;
PMID: 37808676
The ribosome is an essential drug target as many classes of clinically important antibiotics bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is targeted by the...
3.
Trautmann H, Schmidt S, Gregory S, Ramsey K
J Bacteriol
. 2023 Sep;
205(9):e0014023.
PMID: 37676009
Although ribosomes are generally examined in aggregate, ribosomes can be heterogenous in composition. Evidence is accumulating that changes in ribosome composition may result in altered function, such that ribosome heterogeneity...
4.
Silvia S, Donahue S, Killeavy E, Jogl G, Gregory S
Antibiotics (Basel)
. 2021 Nov;
10(11).
PMID: 34827322
is a halophilic extreme thermophile, with potential as a model organism for studies of the structural basis of antibiotic resistance. In order to facilitate genetic studies of this organism, we...
5.
Svetlov M, Syroegin E, Aleksandrova E, Atkinson G, Gregory S, Mankin A, et al.
Nat Chem Biol
. 2021 Jan;
17(4):412-420.
PMID: 33462493
Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein biosynthesis. Macrolides represent one of the most successful classes of ribosome-targeting antibiotics. The main clinically relevant...
6.
Murphy E, Singh K, Avila B, Kleffmann T, Gregory S, Murray B, et al.
Sci Rep
. 2020 Oct;
10(1):16301.
PMID: 33004869
Enterococcus faecalis is a gram-positive organism responsible for serious infections in humans, but as with many bacterial pathogens, resistance has rendered a number of commonly used antibiotics ineffective. Here, we...
7.
Younkin A, Gregory S, OConnor M
Biochimie
. 2020 Jun;
175:173-180.
PMID: 32569619
In bacteria, ribosomal protein bL12 forms the prominent stalk structure on the ribosome and binds to multiple, distinct translational GTPase factors during the sequential steps of translation. Using a genetic...
8.
Killeavy E, Jogl G, Gregory S
Antibiotics (Basel)
. 2020 Jun;
9(6).
PMID: 32526926
Tiamulin is a semisynthetic pleuromutilin antibiotic that binds to the 50S ribosomal subunit A site and whose (((2-diethylamino)ethyl)thio)-acetic acid tail extends into the P site to interfere with peptide bond...
9.
Kamath D, Allgeyer B, Gregory S, Bielski M, Roelofsz D, Sabapathypillai S, et al.
Biochimie
. 2017 May;
138:194-201.
PMID: 28483689
Ribosomal protein uS4 is an essential ribosomal component involved in multiple functions, including mRNA decoding. Structural analyses indicate that during decoding, the interface between the C-terminus of uS4 and protein...
10.
Kamath D, Gregory S, OConnor M
Antimicrob Agents Chemother
. 2016 Nov;
61(2).
PMID: 27855073
Ribosomal protein uS5 is an essential component of the small ribosomal subunit that is involved in subunit assembly, maintenance of translational fidelity, and the ribosome's response to the antibiotic spectinomycin....