Eileen L Murphy
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Explore the profile of Eileen L Murphy including associated specialties, affiliations and a list of published articles.
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8
Citations
96
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Recent Articles
1.
Newton J, Naik M, Li G, Murphy E, Fawzi N, Sedivy J, et al.
Biophys J
. 2021 Apr;
120(11):2181-2191.
PMID: 33798566
Long interspersed nuclear element-1 (L1) is a retrotransposable element that autonomously replicates in the human genome, resulting in DNA damage and genomic instability. Activation of L1 in senescent cells triggers...
2.
Murphy E, Singh K, Avila B, Kleffmann T, Gregory S, Murray B, et al.
Sci Rep
. 2020 Oct;
10(1):16301.
PMID: 33004869
Enterococcus faecalis is a gram-positive organism responsible for serious infections in humans, but as with many bacterial pathogens, resistance has rendered a number of commonly used antibiotics ineffective. Here, we...
3.
Cygan K, Soemedi R, Rhine C, Profeta A, Murphy E, Murray M, et al.
Hum Genet
. 2017 Aug;
136(9):1303-1312.
PMID: 28780672
Defective splicing is a common cause of genetic diseases. On average, 13.4% of all hereditary disease alleles are classified as splicing mutations with most mapping to the critical GT or...
4.
Demirci H, Murphy 4th F, Murphy E, Connetti J, Dahlberg A, Jogl G, et al.
Antimicrob Agents Chemother
. 2014 May;
58(8):4308-17.
PMID: 24820088
Streptomycin is a bactericidal antibiotic that induces translational errors. It binds to the 30S ribosomal subunit, interacting with ribosomal protein S12 and with 16S rRNA through contacts with the phosphodiester...
5.
Demirci H, Wang L, Murphy 4th F, Murphy E, Carr J, Blanchard S, et al.
RNA
. 2013 Oct;
19(12):1791-801.
PMID: 24152548
The ribosome decodes mRNA by monitoring the geometry of codon-anticodon base-pairing using a set of universally conserved 16S rRNA nucleotides within the conformationally dynamic decoding site. By applying single-molecule FRET...
6.
Bergeron K, Murphy E, Brown L, Almeida K
Protein J
. 2010 Nov;
30(1):1-8.
PMID: 21113733
The American Cancer Society's 2009 statistics estimate that 1 out of every 4 deaths is cancer related. Genomic instability is a common feature of cancerous states, and an increase in...
7.
Bergeron K, Murphy E, Majofodun O, Munoz L, Williams Jr J, Almeida K
Mutat Res
. 2009 May;
673(2):141-8.
PMID: 19429515
Arylphosphonium salts (APS) are compounds that have both lipophilic and cationic character, allowing them facile transport through plasma membranes or cell walls to accumulate in the cytoplasm or mitochondria of...
8.
Strych U, Davlieva M, Longtin J, Murphy E, Im H, Benedik M, et al.
BMC Microbiol
. 2007 May;
7:40.
PMID: 17509154
Background: Over the past fifteen years, antibiotic resistance in the Gram-positive opportunistic human pathogen Streptococcus pneumoniae has significantly increased. Clinical isolates from patients with community-acquired pneumonia or otitis media often...