Patrick A Limbach
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Explore the profile of Patrick A Limbach including associated specialties, affiliations and a list of published articles.
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155
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3537
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Recent Articles
1.
Devarkar S, Budding C, Pathirage C, Kavoor A, Herbert C, Limbach P, et al.
Nucleic Acids Res
. 2025 Mar;
53(5).
PMID: 40036503
The average eukaryotic transfer ribonucleic acid (tRNA) contains 13 post-transcriptional modifications; however, their functional impact is largely unknown. Our understanding of the complex tRNA aminoacylation machinery in metazoans also remains...
2.
Hwang S, Liao H, Barondeau K, Han X, Herbert C, McConie H, et al.
Cell Rep
. 2025 Jan;
44(1):115167.
PMID: 39786998
tRNA modifications are critical for several aspects of their functions, including decoding, folding, and stability. Using a multifaceted approach encompassing eCLIP-seq and nanopore tRNA-seq, we show that the human tRNA...
3.
Devarkar S, Budding C, Pathirage C, Kavoor A, Herbert C, Limbach P, et al.
bioRxiv
. 2024 Dec;
PMID: 39677689
The average eukaryotic tRNA contains 13 posttranscriptional modifications; however, their functional impact is largely unknown. Our understanding of the complex tRNA aminoacylation machinery in metazoans also remains limited. Herein, using...
4.
Abernathy S, Rayhan A, Limbach P
Analyst
. 2024 Nov;
150(1):185-196.
PMID: 39611213
The use of liquid chromatography coupled with mass spectrometry (LC-MS) for the characterization of oligonucleotides and nucleic acids is a powerful analytical method. Recently, hydrophilic interaction chromatography (HILIC) has been...
5.
Valesyan S, Jora M, Addepalli B, Limbach P
Proc Natl Acad Sci U S A
. 2024 Nov;
121(46):e2317857121.
PMID: 39495928
There has been recent interest in trying to understand the connection between transfer RNA (tRNA) posttranscriptional modifications and changes in-cellular environmental conditions. Here, we report on the identification of the...
6.
Hwang S, Liao H, Barondeau K, Han X, Herbert C, McConie H, et al.
bioRxiv
. 2024 Oct;
PMID: 39416027
tRNA modifications are critical for several aspects of their functions, including decoding, folding, and stability. Using a multifaceted approach encompassing eCLIP-seq and Nanopore tRNA-seq, we show that the human tRNA...
7.
Kelley M, Holmes C, Herbert C, Rayhan A, Joves J, Uhran M, et al.
Insect Mol Biol
. 2024 Aug;
34(1):65-80.
PMID: 39105593
Mosquitoes such as Aedes aegypti must consume a blood meal for the nutrients necessary for egg production. Several transcriptome and proteome changes occur post-blood meal that likely corresponds with codon...
8.
Herbert C, Valesyan S, Kist J, Limbach P
Annu Rev Anal Chem (Palo Alto Calif)
. 2024 Apr;
17(1):47-68.
PMID: 38594935
Ribonucleic acids (RNAs) are key biomolecules responsible for the transmission of genetic information, the synthesis of proteins, and modulation of many biochemical processes. They are also often the key components...
9.
Baek A, Rayhan A, Lee G, Golconda S, Yu H, Kim S, et al.
Methods Protoc
. 2024 Jan;
7(1).
PMID: 38251200
The biological significance of chemical modifications to the ribonucleic acid (RNA) of human immunodeficiency virus type-1 (HIV-1) has been recognized. However, our understanding of the site-specific and context-dependent roles of...
10.
Herbert C, Ohrnberger C, Quinlisk E, Addepalli B, Limbach P
Biomedicines
. 2023 Dec;
11(12).
PMID: 38137491
The activated forms of the environmental pollutant benzo[a]pyrene (B[a]P), such as benzo[a]pyrene diol epoxide (BPDE), are known to cause damage to genomic DNA and proteins. However, the impact of BPDE...