Steven Seaman
Overview
Explore the profile of Steven Seaman including associated specialties, affiliations and a list of published articles.
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21
Citations
4367
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Recent Articles
1.
Yang L, Sheets T, Feng Y, Yu G, Bajgain P, Hsu K, et al.
Sci Adv
. 2024 Feb;
10(7):eadj2445.
PMID: 38354234
The majority of clinically approved drugs target proteins that are secreted or cell surface bound. However, further advances in this area have been hindered by the challenging nature of receptor...
2.
Feng Y, Lee J, Yang L, Hilton M, Morris K, Seaman S, et al.
Cell Rep
. 2023 Nov;
42(12):113503.
PMID: 38019654
CD276/B7-H3 represents a promising target for cancer therapy based on widespread overexpression in both cancer cells and tumor-associated stroma. In previous preclinical studies, CD276 antibody-drug conjugates (ADCs) exploiting a talirine-type...
3.
Hsu K, Dunleavey J, Szot C, Yang L, Hilton M, Morris K, et al.
Nat Commun
. 2022 Nov;
13(1):7078.
PMID: 36400786
Collagen I, the most abundant protein in humans, is ubiquitous in solid tumors where it provides a rich source of exploitable metabolic fuel for cancer cells. While tumor cells were...
4.
Lee M, Lu Z, Shoemaker C, Tremblay J, St Croix B, Seaman S, et al.
J Control Release
. 2021 Apr;
334:106-113.
PMID: 33872627
For the developing field of gene therapy the successful address of the basic requirement effective gene delivery has remained a critical barrier. In this regard, the "Holy Grail" vector envisioned...
5.
Kendsersky N, Lindsay J, Kolb E, Smith M, Teicher B, Erickson S, et al.
Clin Cancer Res
. 2021 Feb;
27(10):2938-2946.
PMID: 33619171
Purpose: Patients with relapsed pediatric solid malignancies have few therapeutic options, and many of these patients die of their disease. B7-H3 is an immune checkpoint protein encoded by the gene...
6.
Gadomski S, Singh S, Singh S, Sarkar T, Klarmann K, Berenschot M, et al.
Cell Rep
. 2020 Apr;
31(4):107572.
PMID: 32348770
Investigating mechanisms that regulate endothelial cell (EC) growth and survival is important for understanding EC homeostasis and how ECs maintain stem cell niches. We report here that targeted loss of...
7.
Johnston M, Nikolic A, Ninkovic N, Guilhamon P, Cavalli F, Seaman S, et al.
Genome Res
. 2019 Jun;
29(8):1211-1222.
PMID: 31249064
We investigated the role of 3D genome architecture in instructing functional properties of glioblastoma stem cells (GSCs) by generating sub-5-kb resolution 3D genome maps by in situ Hi-C. Contact maps...
8.
Szot C, Saha S, Zhang X, Zhu Z, Hilton M, Morris K, et al.
J Clin Invest
. 2018 Jun;
128(7):2927-2943.
PMID: 29863500
Although nonmalignant stromal cells facilitate tumor growth and can occupy up to 90% of a solid tumor mass, better strategies to exploit these cells for improved cancer therapy are needed....
9.
Byrd T, Fousek K, Pignata A, Szot C, Samaha H, Seaman S, et al.
Cancer Res
. 2017 Nov;
78(2):489-500.
PMID: 29183891
Triple-negative breast cancer (TNBC) is an aggressive disease lacking targeted therapy. In this study, we developed a CAR T cell-based immunotherapeutic strategy to target TEM8, a marker initially defined on...
10.
Seaman S, Zhu Z, Saha S, Zhang X, Yang M, Hilton M, et al.
Cancer Cell
. 2017 Apr;
31(4):501-515.e8.
PMID: 28399408
Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several obstacles, including identification of suitable targets and optimal...