Gui-in Lee
Overview
Explore the profile of Gui-in Lee including associated specialties, affiliations and a list of published articles.
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11
Citations
231
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Recent Articles
1.
Wang X, Saludes J, Zhao T, Csakai A, Fiorini Z, Chavez S, et al.
Biochim Biophys Acta
. 2012 May;
1818(9):2282-9.
PMID: 22609737
The lateral transmembrane protein-protein interaction has been regarded as "undruggable" despite its importance in many biological processes. The homo-trimerization of transmembrane domain 5 (TMD-5) of latent membrane protein 1 (LMP-1)...
2.
Rodriguez J, Ross N, Katt W, Dhar D, Lee G, Hamilton A
ChemMedChem
. 2009 Mar;
4(4):649-56.
PMID: 19330783
The Bcl-x(L)/Bak protein-protein interaction has emerged as an important target for cancer therapy due to its role in apoptosis. Inhibition of this interaction by small-molecule antagonists induces apoptosis in unhealthy...
3.
Rodriguez J, Nevola L, Ross N, Lee G, Hamilton A
Chembiochem
. 2009 Mar;
10(5):829-33.
PMID: 19263447
No abstract available.
4.
Slivka P, Shridhar M, Lee G, Sammond D, Hutchinson M, Martinko A, et al.
Chembiochem
. 2009 Feb;
10(4):645-9.
PMID: 19184989
Toll-like receptors are an integral part of innate immunity in the central nervous system (CNS); they orchestrate a robust defense in response to both exogenous and endogenous danger signals. Recently,...
5.
Liang X, Lee G, Van Doren S
J Mol Biol
. 2006 Sep;
364(2):225-40.
PMID: 17007879
FHA domains adopt a beta-sandwich fold with 11 strands. The first evidence of partially unfolded forms of a beta-sandwich is derived from native-state hydrogen exchange (NHX) of the forkhead-associated (FHA)...
6.
Ding Z, Lee G, Liang X, Gallazzi F, Arunima A, Van Doren S
Biochemistry
. 2005 Jul;
44(30):10119-34.
PMID: 16042389
A net increase in the backbone rigidity of the kinase-interacting FHA domain (KI-FHA) from the Arabidopsis receptor kinase-associated protein phosphatase (KAPP) accompanies the binding of a phosphoThr peptide from its...
7.
Yin H, Lee G, Sedey K, Kutzki O, Park H, Orner B, et al.
J Am Chem Soc
. 2005 Jul;
127(29):10191-6.
PMID: 16028929
We describe a general method for the mimicry of one face of an alpha-helix based on a terphenyl scaffold that spatially projects functionality in a manner similar to that of...
8.
Yin H, Lee G, Sedey K, Rodriguez J, Wang H, Sebti S, et al.
J Am Chem Soc
. 2005 Apr;
127(15):5463-8.
PMID: 15826183
A series of Bcl-x(L)/Bak antagonists, based on a terephthalamide scaffold, was designed to mimic the alpha-helical region of the Bak peptide. These molecules showed favorable in vitro activities in disrupting...
9.
Yin H, Lee G, Park H, Payne G, Rodriguez J, Sebti S, et al.
Angew Chem Int Ed Engl
. 2005 Mar;
44(18):2704-2707.
PMID: 15765497
No abstract available.
10.
Lee G, Ding Z, Walker J, Van Doren S
Proc Natl Acad Sci U S A
. 2003 Sep;
100(20):11261-6.
PMID: 14500786
Forkhead-associated (FHA) domains are phosphoprotein-binding modules found in diverse signaling proteins that bind partners phosphorylated on threonine or serine. Kinase-associated protein phosphatase from Arabidopsis employs its FHA domain for negative...