Steven R LaPlante
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Explore the profile of Steven R LaPlante including associated specialties, affiliations and a list of published articles.
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57
Citations
800
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Recent Articles
11.
Shahout F, Vanharen M, Saafane A, Gillard J, Girard D, LaPlante S
Mol Pharm
. 2023 Jul;
20(8):4031-4040.
PMID: 37421372
The free-state solution behaviors of small molecules profoundly affect their respective properties. It is becoming more obvious that compounds can adopt a three-phase equilibrium when placed in an aqueous solution,...
12.
Ribeiro R, Botelho F, Pinto A, La Torre A, Almeida J, LaPlante S, et al.
J Mol Model
. 2023 May;
29(6):183.
PMID: 37212923
Context: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 infection and responsible for millions of victims worldwide, remains a significant threat to public health....
13.
Ali Z, Cardoza J, Basak S, Narsaria U, Singh V, Isaac S, et al.
J Biomol Struct Dyn
. 2023 Feb;
41(22):13348-13367.
PMID: 36744449
The COVID-19 pandemic caused by SARS-CoV-2 virus has created a global damage and has exposed the vulnerable side of scientific research towards novel diseases. The intensity of the pandemic is...
14.
Sow A, Pahmeier F, Ayotte Y, Anton A, Mazeaud C, Charpentier T, et al.
Antimicrob Agents Chemother
. 2023 Jan;
67(2):e0133122.
PMID: 36700643
Dengue virus (DENV) is a that causes the most prevalent arthropod-borne viral disease. Clinical manifestation of DENV infection ranges from asymptomatic to severe symptoms that can lead to death. Unfortunately,...
15.
Aghamohammadi M, Sirouspour M, Goncalves A, Franca T, LaPlante S, Shahdousti P
J Mol Model
. 2022 Nov;
28(12):380.
PMID: 36342543
In response to the COVID-19 pandemic, and the lack of effective and safe antivirals against it, we adopted a new approach in which food supplements with vital antiviral characteristics, low...
16.
Franca T, Botelho F, Drummond M, LaPlante S
ACS Omega
. 2022 Sep;
7(36):32805-32815.
PMID: 36120038
Recently, we reported a library of 82 compounds, selected from different databanks through virtual screening and docking studies, and pointed to 6 among them as potential repurposed dual binders to...
17.
Santos M, Botelho F, Goncalves A, Kitagawa D, Borges C, Carvalho-Silva T, et al.
Arch Toxicol
. 2022 Jun;
96(9):2559-2572.
PMID: 35666269
The misuse of novichok agents in assassination attempts has been reported in the international media since 2018. These relatively new class of neurotoxic agents is claimed to be more toxic...
18.
Ayotte Y, Woo S, LaPlante S
ACS Omega
. 2022 Apr;
7(15):13155-13163.
PMID: 35474811
Fluorine (F) NMR strategies are increasingly being employed for evaluating ligand binding to macromolecules, among many other uses. F NMR offers many advantages as a result of its sensitive spin...
19.
Farahani M, Franca T, Alapour S, Shahout F, Boulon R, Iddir M, et al.
ChemMedChem
. 2022 Mar;
17(10):e202200092.
PMID: 35298873
A focused drug repurposing approach is described where an FDA-approved drug is rationally selected for biological testing based on structural similarities to a fragment compound found to bind a target...
20.
LaPlante S, Roux V, Shahout F, LaPlante G, Woo S, Denk M, et al.
Nat Protoc
. 2021 Oct;
16(11):5250-5273.
PMID: 34707256
The free-state solution behaviors of drugs profoundly affect their properties. Therefore, it is critical to properly evaluate a drug's unique multiphase equilibrium when in an aqueous enviroment, which can comprise...