Steven M Romanelli
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Explore the profile of Steven M Romanelli including associated specialties, affiliations and a list of published articles.
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10
Citations
135
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Recent Articles
1.
Li Z, Bowers E, Zhu J, Yu H, Hardij J, Bagchi D, et al.
Elife
. 2022 Jun;
11.
PMID: 35731039
To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride lipase (ATGL, gene). BMAd-...
2.
Cui L, Pereira S, Sonzini S, van Pelt S, Romanelli S, Liang L, et al.
Nanoscale
. 2022 Jan;
14(4):1480-1491.
PMID: 35024714
mRNA lipid nanoparticles (LNPs) are at the forefront of nucleic acid intracellular delivery, as exemplified by the recent emergency approval of two mRNA LNP-based COVID-19 vaccines. The success of an...
3.
Cui L, Hunter M, Sonzini S, Pereira S, Romanelli S, Liu K, et al.
Small
. 2021 Dec;
18(9):e2105832.
PMID: 34914866
Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for COVID-19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which enable functional intracellular...
4.
Romanelli S, Lewis K, Nishii A, Rupp A, Li Z, Mori H, et al.
J Biol Chem
. 2021 Nov;
297(6):101402.
PMID: 34774798
CRISPR/Cas9 has enabled inducible gene knockout in numerous tissues; however, its use has not been reported in brown adipose tissue (BAT). Here, we developed the brown adipocyte CRISPR (BAd-CRISPR) methodology...
5.
The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures
Mori H, Dugan C, Nishii A, Benchamana A, Li Z, Cadenhead 4th T, et al.
PLoS Biol
. 2021 May;
19(5):e3000988.
PMID: 33979328
Although visceral adipocytes located within the body's central core are maintained at approximately 37°C, adipocytes within bone marrow, subcutaneous, and dermal depots are found primarily within the peripheral shell and...
6.
Viral and Nonviral Transfer of Genetic Materials to Adipose Tissues: Toward a Gold Standard Approach
Romanelli S, MacDougald O
Diabetes
. 2020 Nov;
69(12):2581-2588.
PMID: 33219099
Gene transfer using viral or nonviral vectors enables the ability to manipulate specific cells and tissues for gene silencing, protein overexpression, or genome modification. Despite the widespread application of viral-...
7.
Bagchi D, Li Z, Corsa C, Hardij J, Mori H, Learman B, et al.
Mol Metab
. 2020 Apr;
39:100992.
PMID: 32325263
Objective: Obesity is a key risk factor for many secondary chronic illnesses, including type 2 diabetes and cardiovascular disease. Canonical Wnt/β-catenin signaling is established as an important endogenous inhibitor of...
8.
Li Z, Hardij J, Evers S, Hutch C, Choi S, Shao Y, et al.
J Clin Invest
. 2019 May;
129(6):2404-2416.
PMID: 31063988
Bariatric surgeries are integral to the management of obesity and its metabolic complications. However, these surgeries cause bone loss and increase fracture risk through poorly understood mechanisms. In a mouse...
9.
Knoll G, Romanelli S, Brown A, Sortino R, Banerjee I
J Nanosci Nanotechnol
. 2016 Jul;
16(3):2464-73.
PMID: 27455656
Peptide based nanomaterials have been gaining increased prominence due to their ability to form permeable scaffolds that promote growth and regeneration of new tissue. In this work for the first...
10.
Romanelli S, Fath K, Phekoo A, Knoll G, Banerjee I
Mater Sci Eng C Mater Biol Appl
. 2015 Apr;
51:316-28.
PMID: 25842141
In this work we have developed a new family of biocomposite scaffolds for bone tissue regeneration by utilizing self-assembled fluorenylmethyloxycarbonyl protected Valyl-cetylamide (FVC) nanoassemblies as templates. To tailor the assemblies...