Steven K Hanks
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Explore the profile of Steven K Hanks including associated specialties, affiliations and a list of published articles.
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41
Citations
1818
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Recent Articles
1.
Sontag J, Schuhmacher D, Taleski G, Jordan A, Khan S, Hoffman A, et al.
J Biol Chem
. 2022 Jul;
298(8):102248.
PMID: 35820485
Protein phosphatase 2A (PP2A) is a major phospho-Ser/Thr phosphatase and a key regulator of cellular signal transduction pathways. While PP2A dysfunction has been linked to human cancer and neurodegenerative disorders...
2.
Zhang C, Miller D, Guibao C, Donato D, Hanks S, Zheng J
J Biol Chem
. 2017 Sep;
292(44):18281-18289.
PMID: 28860193
The Cas family scaffolding protein p130Cas is a Src substrate localized in focal adhesions (FAs) and functions in integrin signaling to promote cell motility, invasion, proliferation, and survival. p130Cas targeting...
3.
Luo W, Janostiak R, Tolde O, Ryzhova L, Koudelkova L, Dibus M, et al.
J Cell Sci
. 2017 Jun;
130(14):2382-2393.
PMID: 28584191
The tyrosine kinase Src acts as a key regulator of cell motility by phosphorylating multiple protein substrates that control cytoskeletal and adhesion dynamics. In an earlier phosphotyrosine proteomics study, we...
4.
Zhu X, Efimova N, Arnette C, Hanks S, Kaverina I
Cytoskeleton (Hoboken)
. 2016 Apr;
73(6):300-15.
PMID: 27105779
Extracellular matrix (ECM) remodeling during physiological processes is mediated by invasive protrusions called podosomes. Positioning and dynamics of podosomes define the extent of ECM degradation. Microtubules are known to be...
5.
Cunningham-Edmondson A, Hanks S
Breast Cancer (Dove Med Press)
. 2013 Dec;
1:39-52.
PMID: 24367162
Elevated Src tyrosine kinase activity is commonly observed in breast cancer and likely contributes to neoplasia and malignancy. p130Cas ("Crk-associated substrate") is a major Src substrate found at the sites...
6.
McKinley E, Liu H, McDonald W, Luo W, Zhao P, Coffey R, et al.
PLoS One
. 2013 Nov;
8(11):e80207.
PMID: 24260357
Sensitive and specific biomarkers of protein kinase inhibition can be leveraged to accelerate drug development studies in oncology by associating early molecular responses with target inhibition. In this study, we...
7.
George B, Verma R, Soofi A, Garg P, Zhang J, Park T, et al.
J Clin Invest
. 2012 Jan;
122(2):674-92.
PMID: 22251701
The morphology of healthy podocyte foot processes is necessary for maintaining the characteristics of the kidney filtration barrier. In most forms of glomerular disease, abnormal filter barrier function results when...
8.
Janostiak R, Tolde O, Bruhova Z, Novotny M, Hanks S, Rosel D, et al.
Mol Biol Cell
. 2011 Sep;
22(22):4256-67.
PMID: 21937722
Crk-associated substrate (CAS) is a major tyrosine-phosphorylated protein in cells transformed by v-crk and v-src oncogenes and plays an important role in invasiveness of Src-transformed cells. A novel phosphorylation site...
9.
Goettel J, Liang D, Hilliard V, Edelblum K, Broadus M, Gould K, et al.
Exp Cell Res
. 2010 Dec;
317(4):452-63.
PMID: 21144847
The extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway is a highly conserved signaling pathway that regulates diverse cellular processes including differentiation, proliferation, and survival. Kinase suppressor of Ras-1 (KSR1) binds...
10.
Meenderink L, Ryzhova L, Donato D, Gochberg D, Kaverina I, Hanks S
PLoS One
. 2010 Oct;
5(10):e13412.
PMID: 20976150
The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical aspects of cell motility including FA disassembly and protrusion of...