Steven K Hanks
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Explore the profile of Steven K Hanks including associated specialties, affiliations and a list of published articles.
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41
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1818
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Recent Articles
11.
Donato D, Ryzhova L, Meenderink L, Kaverina I, Hanks S
J Biol Chem
. 2010 May;
285(27):20769-79.
PMID: 20430882
The docking protein p130Cas is a major Src substrate involved in integrin signaling and mechanotransduction. Tyrosine phosphorylation of p130Cas in focal adhesions (FAs) has been linked to enhanced cell migration,...
12.
Dumbauld D, Michael K, Hanks S, Garcia A
Biol Cell
. 2009 Nov;
102(4):203-213.
PMID: 19883375
Background Information: FAK (focal adhesion kinase), an essential non-receptor tyrosine kinase, plays pivotal roles in migratory responses, adhesive signalling and mechanotransduction. FAK-dependent regulation of cell migration involves focal adhesion turnover...
13.
Ciccimaro E, Hanks S, Yu K, Blair I
Anal Chem
. 2009 Apr;
81(9):3304-13.
PMID: 19354260
A vital point of convergence for many signaling pathways at cellular focal adhesions is the interaction of two nonreceptor tyrosine kinases, focal adhesion kinase (FAK) and Src. The binding of...
14.
Michael K, Dumbauld D, Burns K, Hanks S, Garcia A
Mol Biol Cell
. 2009 Mar;
20(9):2508-19.
PMID: 19297531
Focal adhesion kinase (FAK) is an essential nonreceptor tyrosine kinase regulating cell migration, adhesive signaling, and mechanosensing. Using FAK-null cells expressing FAK under an inducible promoter, we demonstrate that FAK...
15.
Ricono J, Huang M, Barnes L, Lau S, Weis S, Schlaepfer D, et al.
Cancer Res
. 2009 Feb;
69(4):1383-91.
PMID: 19208836
Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. Previously, we showed that epidermal growth factor (EGF) stimulation of pancreatic carcinoma cells led to invasion...
16.
Ciccimaro E, Hanks S, Blair I
Mol Pharmacol
. 2008 Dec;
75(3):658-66.
PMID: 19098120
A recently developed stable isotope dilution liquid chromatography-multiple reaction/mass spectrometry method to quantify focal adhesion kinase (FAK) activation loop phosphorylation was used to study endogenous Src kinase activity. This revealed...
17.
Constancio-Lund S, Brabek J, Hanks S
Mol Carcinog
. 2008 Jul;
48(2):156-66.
PMID: 18613032
Colon cancer arises through a multistep process involving inactivation of tumor suppressor proteins and activation of oncogene-encoded proteins. Development of colon cancer frequently involves mutation of the adenomatous polyposis coli...
18.
Luo W, Slebos R, Hill S, Li M, Brabek J, Amanchy R, et al.
J Proteome Res
. 2008 Jun;
7(8):3447-60.
PMID: 18563927
Elevated activity of Src, the first characterized protein-tyrosine kinase, is associated with progression of many human cancers, and Src has attracted interest as a therapeutic target. Src is known to...
19.
Kim W, Kang Y, Kim J, Shin N, Hanks S, Song W
Mol Biol Cell
. 2008 Mar;
19(5):2135-46.
PMID: 18321991
Reciprocal cooperative signaling by integrins and growth factor receptors at G1 phase during cell cycle progression is well documented. By contrast, little is known about the cross-talk between integrin and...
20.
Siesser P, Meenderink L, Ryzhova L, Michael K, Dumbauld D, Garcia A, et al.
Cell Motil Cytoskeleton
. 2007 Oct;
65(1):25-39.
PMID: 17922492
Formation of a complex between the tyrosine kinases FAK and Src is a key integrin-mediated signaling event implicated in cell motility, survival, and proliferation. Past studies indicate that FAK functions...