Steven J Coultrap
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Explore the profile of Steven J Coultrap including associated specialties, affiliations and a list of published articles.
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40
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1350
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Recent Articles
1.
Rumian N, Barker C, Larsen M, Tullis J, Freund R, Taslimi A, et al.
Cell Rep
. 2024 Oct;
43(10):114866.
PMID: 39395168
Learning and memory are thought to require the induction and maintenance of long-term potentiation (LTP) of synaptic strength. LTP induction requires the Ca/calmodulin-dependent protein kinase II (CaMKII) but for structural...
2.
Tullis J, Larsen M, Rumian N, Freund R, Boxer E, Brown C, et al.
Nature
. 2023 Aug;
621(7977):146-153.
PMID: 37648853
Learning and memory are thought to require hippocampal long-term potentiation (LTP), and one of the few central dogmas of molecular neuroscience that has stood undisputed for more than three decades...
3.
Rumian N, Freund R, DellAcqua M, Coultrap S, Bayer K
Sci Signal
. 2023 Jul;
16(795):eade5892.
PMID: 37490545
CaMKII has molecular memory functions because transient calcium ion stimuli can induce long-lasting increases in its synaptic localization and calcium ion-independent (autonomous) activity, thereby leaving memory traces of calcium ion...
4.
Brown C, Rumian N, Tullis J, Coultrap S, Bayer K
iScience
. 2022 May;
25(6):104368.
PMID: 35620430
Aβ bears homology to the CaMKII regulatory domain, and peptides derived from this domain can bind and disrupt the CaMKII holoenzyme, suggesting that Aβ could have a similar effect. Notably,...
5.
Buonarati O, Miller A, Coultrap S, Bayer K, Reichow S
Cell Rep
. 2021 Dec;
37(13):110168.
PMID: 34965414
Neuronal CaMKII holoenzymes (α and β isoforms) enable molecular signal computation underlying learning and memory but also mediate excitotoxic neuronal death. Here, we provide a comparative analysis of these signaling...
6.
Tullis J, Buonarati O, Coultrap S, Bourke A, Tiemeier E, Kennedy M, et al.
iScience
. 2021 Oct;
24(10):103214.
PMID: 34704002
Binding of two different CaM kinases, CaMKII and DAPK1, to the NMDA-type glutamate receptor (NMDAR) subunit GluN2B near S1303 has been implicated in excitotoxic/ischemic neuronal cell death. The GluN2B mutation...
7.
Brown C, Cook S, Allen H, Crosby K, Singh T, Coultrap S, et al.
iScience
. 2021 Oct;
24(10):103184.
PMID: 34667946
The Ca/Calmodulin-dependent protein kinase II (CaMKII) is a central regulator of synaptic plasticity and has been implicated in various neurological conditions, including schizophrenia. Here, we characterize six different CaMKIIα variants...
8.
Cook S, Buonarati O, Coultrap S, Bayer K
Sci Adv
. 2021 Apr;
7(16).
PMID: 33853773
Higher brain functions are thought to require synaptic frequency decoding that can lead to long-term potentiation (LTP) or depression (LTD). We show that the LTP versus LTD decision is determined...
9.
Buonarati O, Cook S, Goodell D, Chalmers N, Rumian N, Tullis J, et al.
Cell Rep
. 2020 Jan;
30(1):1-8.e4.
PMID: 31914378
DAPK1 binding to GluN2B was prominently reported to mediate ischemic cell death in vivo. DAPK1 and CaMKII bind to the same GluN2B region, and their binding is mutually exclusive. Here,...
10.
Opazo P, Viana da Silva S, Carta M, Breillat C, Coultrap S, Grillo-Bosch D, et al.
Cell Rep
. 2018 Jun;
23(11):3137-3145.
PMID: 29898386
Alzheimer's disease (AD) is emerging as a synaptopathology driven by metaplasticity. Indeed, reminiscent of metaplasticity, oligomeric forms of the amyloid-β peptide (oAβ) prevent induction of long-term potentiation (LTP) via the...